tert-butyl 4-(2-cyanobenzoyl)-1-piperazinecarboxylate | 412930-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-(2-cyanobenzoyl)-1-piperazinecarboxylate
• 英文别名: Tert-butyl 4-(2-cyanobenzoyl)piperazine-1-carboxylate
• CAS: 412930-98-4
• 化学式: C₁₇H₂₁N₃O₃
• 分子量: 315.372
• InChiKey: RRPZELISZVPCFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  73.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(2-cyanobenzoyl)-1-piperazinecarboxylate 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 、 氯仿 为溶剂， 20.0 ℃ 、344.75 kPa 条件下， 生成 tert-butyl 4-(2-aminomethylbenzoyl)piperazine-1-carboxylate
  参考文献：
  名称：

  [EN] NEW ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  [FR] NOUVEAUX DÉRIVÉS D'ARYLSULFONYLGLYCINE, LEUR FABRICATION ET LEUR UTILISATION EN TANT QUE MÉDICAMENTS

  摘要：

  这项发明涉及通式（I）中取代芳基磺酰甘氨酸衍生物，其中基团Ra至Rf、A和Z的定义如规范和索赔中所述，适用于制备用于治疗代谢紊乱，特别是1型或2型糖尿病的药物组合物。

  公开号：

  WO2009127723A1

文献信息

• New derivatives of cyano-aryl (or cyanoheteroaryl) -carbonyl- piperazinyl - pyrimidines, their preparation and application as medication
  申请人：——

  公开号：US20040048872A1

  公开（公告）日：2004-03-11

  New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R 1 represents an OR 3 radical, where R 3 represents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4 carbon atoms, and R 2 represents a phenyl radical substituted at least by one cyan radical (—C≡N), or a radical of a heteroaromatic ring of 5 or 6 members substituted at least by one cyan radical (—C≡N); and their physiologically acceptable salts, are useful for application in human and/or veterinary therapeutics as sedatives, anticonvulsants, hypnotics and general anaesthetics. 1

  新的氰基芳基（或氰基杂芳基）-羰基哌嗪嘧啶（I）的衍生物，其中R1代表一个OR3基团，其中R3代表来自饱和碳氢化合物的基团，具有1至4个碳原子的直链或支链，R2代表至少被一个氰基（-C≡N）取代的苯基基团，或者是至少被一个氰基（-C≡N）取代的5或6元杂芳环的基团；以及它们的生理上可接受的盐，可用于人类和/或兽医治疗中作为镇静剂，抗惊厥剂，催眠剂和全身麻醉剂。
• ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：Langkopf Elke

  公开号：US20110269761A1

  公开（公告）日：2011-11-03

  The invention relates to substituted aryl-sulphonylglycine derivatives of general formula (I) wherein the groups R a to R f , A and Z are defined as in the specification and claims, which are suitable for preparing a pharmaceutical composition for the treatment of metabolic disorders, particularly type 1 or type 2 diabetes mellitus.

  本发明涉及一种通式（I）的取代芳基磺酰基甘氨酸衍生物，其中基团R至Rf、A和Z的定义如规范和要求中所述，适用于制备治疗代谢性疾病，特别是1型或2型糖尿病的药物组合物。
• NEW DERIVATIVES OF CYANO-ARYL (OR CYANOHETEROARYL)-CARBONYL-PIPERAZINYL-PYRIMIDINES, THEIR PREPARATION AND APPLICATION AS MEDICATION
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1327630A1

  公开（公告）日：2003-07-16

  New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), wherein R1 represents an OR3 radical, wherein R3 represents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4 carbon atoms, and R2 represents a phenyl radical substituted at least by one cyano radical (-C≡N), or a radical of a heteroaromatic ring of 5 or 6 members substituted at least by one cyano radical (-C≡N); and their physiologically acceptable salts, are useful for application in human and/or veterinary therapeutics as sedatives, anticonvulsants, hypnotics and general anaesthetics.

  氰基芳基（或氰基杂芳基）-羰基哌嗪基嘧啶的新衍生物(I)，其中 R1 代表 OR3 基，R3 代表来自饱和烃的基，具有 1 至 4 个碳原子的线性或支链，R2 代表至少被一个氰基（-C≡N）取代的苯基，或至少被一个氰基（-C≡N）取代的 5 或 6 个杂芳环的基；及其生理上可接受的盐类，可作为镇静剂、抗惊厥剂、催眠剂和全身麻醉剂用于人类和/或兽医治疗。
• NEW ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：EP2279173A1

  公开（公告）日：2011-02-02
• US7300937B2
  申请人：——

  公开号：US7300937B2

  公开（公告）日：2007-11-27