(+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride | 1254942-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
• 英文别名: (s)-7-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline mono-hcl salt；(4S)-4-(3,4-dichlorophenyl)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1,2,3,4-tetrahydroisoquinoline;hydrochloride
• CAS: 1254942-02-3
• 化学式: C₂₁H₁₆Cl₂N₄*ClH
• 分子量: 431.752
• InChiKey: XZLQDUUDCFERFE-FERBBOLQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.36
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 、 水 以 异丙醇 为溶剂， 以Long needle crystals of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline mono-HCl monoisopropanolate monohydrate salt were obtained的产率得到(S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline mono-HCl monoisopropanolate monohydrate
  参考文献：
  名称：

  ARYL, HETEROARYL, AND HETEROCYCLE SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF

  摘要：

  本发明描述了新型取代四氢异喹啉，其中包括芳基、杂环芳基和非芳杂环芳基。这些化合物可用于治疗各种神经和生理疾病。本发明还描述了制备这些化合物的方法。

  公开号：

  US20100292242A1
• 作为产物：
  描述：

  (+)-tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinolin-2(1H)-carboxylate 在 盐酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 2.0h， 以97%的产率得到(+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
  参考文献：
  名称：

  [EN] CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
  [FR] FORMES CRISTALLINES DE (S)-7-([1,2,4]TRIAZOLO[1,5-A] PYRIDIN -6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE ET LEURS UTILISATIONS

  摘要：

  本发明描述了新型[1,2,4]三唑并[1,5-a]吡啶基-6-基取代的四氢异喹啉化合物。这些化合物和结晶形式SA1和N-2被用于治疗各种神经和生理疾病。本发明还描述了制备这些化合物和结晶形式SA-1和N-2的方法。

  公开号：

  WO2010132487A1

文献信息

• 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
  申请人：Liu Shuang

  公开号：US08802696B2

  公开（公告）日：2014-08-12

  Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.

  本发明描述了Novel [1,2,4]三唑并[1,5-a]吡啶基-6-基取代的四氢异喹啉。这些化合物和结晶形式SA1和N-2用于治疗各种神经和生理障碍。本发明还描述了制备这些化合物和结晶形式SA-1和N-2的方法。
• Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
  申请人：Wei Chenkou

  公开号：US08815894B2

  公开（公告）日：2014-08-26

  Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.

  本发明描述了[1,2,4]三唑并[1,5-a]吡啶基-6-基取代的四氢异喹啉类新型化合物。这些化合物及其晶体形式SA1和N-2可用于治疗各种神经和生理障碍。本发明还描述了制备这些化合物和晶体形式SA-1和N-2的方法。
• Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
  申请人：Liu Shuang

  公开号：US09034899B2

  公开（公告）日：2015-05-19

  Novel aryl, heteroaryl, and non-aromatic heterocyle substituted tetrahydroisoquinolines are described in the present invention. These compounds are used in the treatment of various neurological and physiological disorders. Methods of making these compounds are also described in the present invention.

  本发明描述了新型芳基、杂环芳基和非芳杂环取代的四氢异喹啉。这些化合物用于治疗各种神经和生理疾病。本发明还描述了制备这些化合物的方法。
• CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
  申请人：Bristol-Myers Squibb Company

  公开号：US20140364441A1

  公开（公告）日：2014-12-11

  Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.

  本发明描述了[1,2,4]三唑并[1,5-a]吡啶基-6-基取代的四氢异喹啉类新型化合物。这些化合物和晶体形态SA1和N-2可用于治疗各种神经和生理障碍。本发明还描述了制备这些化合物和晶体形态SA-1和N-2的方法。
• Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a ]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
  申请人：Bristol-Myers Squibb Company

  公开号：US09173879B2

  公开（公告）日：2015-11-03

  Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.

  本发明描述了[1,2,4]三唑并[1,5-a]吡啶基-6-基取代四氢异喹啉类化合物。这些化合物及其晶体形式SA1和N-2用于治疗各种神经和生理疾病。本发明还描述了制备这些化合物及晶体形式SA-1和N-2的方法。