3-O-tert-butyl 5-O-methyl 6-(3-phenylphenyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3,5-dicarboxylate | 900158-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-O-tert-butyl 5-O-methyl 6-(3-phenylphenyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3,5-dicarboxylate
• CAS: 900158-10-3
• 化学式: C₂₄H₂₇NO₅
• 分子量: 409.482
• InChiKey: ZWDCZGURPZOGNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  68.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-O-tert-butyl 5-O-methyl 6-(3-phenylphenyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3,5-dicarboxylate 在 sodium methylate 、 碳酸氢钠 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 生成 1-O-tert-butyl 5-O-methyl 3-hydroxy-4-(3-phenylphenyl)-3,6-dihydro-2H-pyridine-1,5-dicarboxylate
  参考文献：
  名称：

  WO2006/94763

  摘要：

  公开号：
• 作为产物：
  描述：

  1-O-tert-butyl 3-O-methyl 4-(3-phenylphenyl)-3,6-dihydro-2H-pyridine-1,3-dicarboxylate 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 3-O-tert-butyl 5-O-methyl 6-(3-phenylphenyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3,5-dicarboxylate
  参考文献：
  名称：

  WO2006/94763

  摘要：

  公开号：

文献信息

• 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES
  申请人：Masuya Keiichi

  公开号：US20100029647A1

  公开（公告）日：2010-02-04

  3,4(,5)-substituted tetrahydropyridine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4(,5)-substituted tetrahydropyridine compound, and/or a method of treatment comprising administering a 3,4(,5)-substituted tetrahydropyridine compound, a method for the manufacture of a 3,4(,5)-substituted tetrahydropyridine compound, and novel intermediates and partial steps for its synthesis. The 3,4(,5)-substituted tetrahydropyridine compounds have the formula I wherein the substituents and symbols are as described in the specification.

  3,4(,5)-取代四氢吡啶化合物，这些化合物用于温血动物的诊断和治疗，特别是用于治疗依赖于肾素活性的疾病；该类化合物用于制备治疗依赖于肾素活性疾病的制药配方；该类化合物用于治疗依赖于肾素活性的疾病；包含3,4(,5)-取代四氢吡啶化合物的制药配方，和/或包括给予3,4(,5)-取代四氢吡啶化合物的治疗方法，以及制备3,4(,5)-取代四氢吡啶化合物的方法，以及其合成的新中间体和部分步骤。3,4(,5)-取代四氢吡啶化合物的化学式为I，其中取代基和符号如说明书所述。
• 3, 4, 5 - Substituted Piperidine Compounds
  申请人：Masuya Keiichi

  公开号：US20100160305A1

  公开（公告）日：2010-06-24

  3,4,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4,5-substituted piperidine compound, a method for the manufacture of a 3,4,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The compounds are of the formula I, wherein the substitutents are as defined in the specification.
• WO2006/94763
  申请人：——

  公开号：——

  公开（公告）日：——