(S)-2.2-dimethyl-3-(6-methoxy-naphthyl-(2))-valeric acid | 20756-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-2.2-dimethyl-3-(6-methoxy-naphthyl-(2))-valeric acid
• 英文别名: (S)-2.2-Dimethyl-3-(6-methoxy-naphthyl-(2))-valeriansaeure；(3S)-3-(6-methoxynaphthalen-2-yl)-2,2-dimethylpentanoic acid
• CAS: 20756-70-1
• 化学式: C₁₈H₂₂O₃
• 分子量: 286.371
• InChiKey: KHLJKRBMZVNZOC-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-2.2-dimethyl-3-(6-methoxy-naphthyl-(2))-valeric acid 在 吡啶盐酸盐 作用下， 生成 (S)-2.2-dimethyl-3-(6-hydroxy-naphthyl-(2))-valeric acid
  参考文献：
  名称：

  Post-translational regulation of Saccharomyces cerevisiae proteins tagged with the hormone-binding domains of mammalian nuclear receptors

  摘要：

  In the post-genome sequencing era the functional analysis of newly discovered proteins becomes more and more important. In this report we describe a genetic approach to the post-translational regulation of protein function in Saccharomyces cerevisiae by creating conditional lethal mutants. The yeast ORFs YDL139c, YDL147w, ERG3 and ERG11 were tagged with sequences encoding the hormone-binding domains of mammalian steroid receptors by PCR-mediated, targeted integration into the yeast genome. We found that se the function of the chimeric proteins is regulated in a hormone-dependent way. This technique provides another important tool for the functional analysis of the yeast preteome.

  DOI：

  10.1007/s004380000325
• 作为产物：
  描述：

  美沙雌酸 在 奎宁 作用下， 生成 (S)-2.2-dimethyl-3-(6-methoxy-naphthyl-(2))-valeric acid
  参考文献：
  名称：

  Post-translational regulation of Saccharomyces cerevisiae proteins tagged with the hormone-binding domains of mammalian nuclear receptors

  摘要：

  In the post-genome sequencing era the functional analysis of newly discovered proteins becomes more and more important. In this report we describe a genetic approach to the post-translational regulation of protein function in Saccharomyces cerevisiae by creating conditional lethal mutants. The yeast ORFs YDL139c, YDL147w, ERG3 and ERG11 were tagged with sequences encoding the hormone-binding domains of mammalian steroid receptors by PCR-mediated, targeted integration into the yeast genome. We found that se the function of the chimeric proteins is regulated in a hormone-dependent way. This technique provides another important tool for the functional analysis of the yeast preteome.

  DOI：

  10.1007/s004380000325

文献信息

• Post-translational regulation of Saccharomyces cerevisiae proteins tagged with the hormone-binding domains of mammalian nuclear receptors
  作者：H. Launhardt、T. Munder

  DOI：10.1007/s004380000325

  日期：2000.10

  In the post-genome sequencing era the functional analysis of newly discovered proteins becomes more and more important. In this report we describe a genetic approach to the post-translational regulation of protein function in Saccharomyces cerevisiae by creating conditional lethal mutants. The yeast ORFs YDL139c, YDL147w, ERG3 and ERG11 were tagged with sequences encoding the hormone-binding domains of mammalian steroid receptors by PCR-mediated, targeted integration into the yeast genome. We found that se the function of the chimeric proteins is regulated in a hormone-dependent way. This technique provides another important tool for the functional analysis of the yeast preteome.