N-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine | 1293987-46-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine
• 英文别名: N-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-7-[2-(trifluoromethyl)phenyl]thieno[3,2-d]pyrimidin-2-amine
• CAS: 1293987-46-8
• 化学式: C₂₄H₂₃F₃N₆S
• 分子量: 484.548
• InChiKey: VMRBGSODJKWWBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  85.4
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2-chloro-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidine 、 6-(4-ethylpiperazin-1-yl)pyridin-3-amine 生成 N-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine
  参考文献：
  名称：

  2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors

  摘要：

  本发明涉及一种2,7-取代噻吩[3,2-d]嘧啶化合物，具有蛋白激酶抑制活性，其药学上可接受的盐以及以该化合物为有效成分的预防和治疗由异常细胞生长引起的疾病的制药组合物。由于新型的2,7-取代噻吩[3,2-d]嘧啶化合物表现出对参与生长因子信号转导的各种蛋白激酶具有优越的抑制活性，因此它可用作预防或治疗由异常细胞生长引起的疾病的药物。

  公开号：

  US08586580B2

文献信息

• 2,7-SUBSTITUTED THIENO[3,2-D] PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：Sim Tae Bo

  公开号：US20120277424A1

  公开（公告）日：2012-11-01

  Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

  揭示了一种具有蛋白激酶抑制活性的2,7-取代噻吩[3,2-d]嘧啶化合物，以及一种药用可接受的盐和药物组合物，用作预防和治疗由异常细胞生长引起的疾病，包括该化合物作为有效成分。由于这种新型的2,7-取代噻吩[3,2-d]嘧啶化合物对参与生长因子信号传导的各种蛋白激酶表现出卓越的抑制活性，因此它可用作预防或治疗由异常细胞生长引起的疾病的药物。
• 2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：KIST Korea Institute of Science and Technology

  公开号：EP2491043A2

  公开（公告）日：2012-08-29
• US8586580B2
  申请人：——

  公开号：US8586580B2

  公开（公告）日：2013-11-19
• [EN] 2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSÉS THIÉNO[3,2-D]PYRIMIDINES SUBSTITUÉS DANS LES POSITIONS 2 ET 7 EN TANT QU'INHIBITEURS DE PROTÉINE KINASE
  申请人：KOREA INST SCI & TECH

  公开号：WO2011049332A2

  公开（公告）日：2011-04-28

  Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.