1-[4-(4-methoxy-phenyl)-piperidin-1-yl]-ethanone | 1276045-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[4-(4-methoxy-phenyl)-piperidin-1-yl]-ethanone
• 英文别名: 1-[4-(4-Methoxyphenyl)piperidin-1-YL]ethan-1-one；1-[4-(4-methoxyphenyl)piperidin-1-yl]ethanone
• CAS: 1276045-16-9
• 化学式: C₁₄H₁₉NO₂
• mdl: MFCD27639913
• 分子量: 233.31
• InChiKey: GSKIJOUSMMGPQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1(2H)-吡啶羧酸,3,6-二氢-4-(4-甲氧苯基)-,1,1-二甲基乙基酯 在 10% palladium on activated charcoal 、 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 1-[4-(4-methoxy-phenyl)-piperidin-1-yl]-ethanone
  参考文献：
  名称：

  Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands

  摘要：

  Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT1 and MT2 receptors are reported. Compounds 11f and 18b (MT1/MT2 agonist) have human microsomal intrinsic clearance comparable to ramelteon. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.068

文献信息

• [EN] 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF<br/>[FR] 2-CYANOPYRROLOPYRIMIDINES ET UTILISATIONS PHARMACEUTIQUES DE CELLES-CI
  申请人：NOVARTIS AG

  公开号：WO2004069256A1

  公开（公告）日：2004-08-19

  The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.

  该发明涉及公式（I）中的吡咯嘧啶，其中Y代表-(CH2)t-O-或-(CH2)r-S-，p为1或2，r为1、2或3，t为1、2或3，或Y为-(CH2)j-或-CH=CH-，j为1或2；p为1或2，或Y为-(CH2)f-，f为1或2，p为1，以及进一步的基团和符号具有如本文所定义的含义；它们的制备，它们作为药物的用途，含有它们的药物组合物，利用这种化合物制备用于治疗神经病性疼痛的药物制剂的用途，以及用于治疗这种疾病的方法在动物中，尤其是在人类中。
• 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF
  申请人：Novartis AG

  公开号：EP1592426B1

  公开（公告）日：2007-12-19
• [EN] 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL<br/>[FR] AMINES OU LACTAMES CYCLIQUES À 6 CHAÎNONS SUBSTITUÉS PAR DE L'URÉE ET DU PHÉNYLE
  申请人：GRUENENTHAL GMBH

  公开号：WO2018054549A1

  公开（公告）日：2018-03-29

  The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.
• Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands
  作者：Guiying Li、Hao Zhou、Yu Jiang、Holger Keim、Sidney W. Topiol、Suresh B. Poda、Yong Ren、Gamini Chandrasena、Darío Doller

  DOI：10.1016/j.bmcl.2010.12.068

  日期：2011.2

  Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT1 and MT2 receptors are reported. Compounds 11f and 18b (MT1/MT2 agonist) have human microsomal intrinsic clearance comparable to ramelteon. (C) 2010 Elsevier Ltd. All rights reserved.