N6-methyldeoxyadenosinetriphosphoric acid | 5085-65-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: N6-methyldeoxyadenosinetriphosphoric acid
• 英文别名: N6-methyl deoxyadenosinetriphosphate；n6-Methyl-2'-deoxyadenosine-5'-triphosphate；[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• CAS: 5085-65-4
• 化学式: C₁₁H₁₈N₅O₁₂P₃
• 分子量: 505.212
• InChiKey: MALRVWPOKBDVSZ-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  245
• 氢给体数：
  6
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  N6-methyldeoxyadenosinetriphosphoric acid 、 N-acetylglucosamine-1-phosphate 在 yeast inorganic pyrophosphatase 、 N-acetylglucosamine-1-phosphate pyrophosphorylase from C_. jejuni NCTC 11168 、 三羟甲基氨基甲烷盐酸盐 、 magnesium chloride 作用下， 反应 2.0h， 以10.8%的产率得到[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [hydroxy-[[(2R,3S,5R)-3-hydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate
  参考文献：
  名称：

  A chemoenzymatic route to synthesize unnatural sugar nucleotides using a novel N-acetylglucosamine-1-phosphate pyrophosphorylase from Camphylobacter jejuni NCTC 11168

  摘要：

  A novel N-acetylglucosamine-1-phosphate pyrophosphorylase was identified from Campylobacter jejuni NCTC 11168. An unprecedented degree of substrate promiscuity has been revealed by systematic studies on its substrate specificities towards sugar-1-P and NTP. The yields of the synthetic reaction of seven kinds of sugar nucleotides catalyzed by the enzyme were up to 60%. In addition, the yields of the other nine were around 20%. With this enzyme, three novel sugar nucleotide analogs were synthesized on a preparative scale and well characterized. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.003

文献信息

• PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS
  申请人：Albericio Fernando

  公开号：US20100144588A1

  公开（公告）日：2010-06-10

  Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.

  包含质子受体的新型亚胺型偶联剂，可有益地用作各种化学多肽和/或多核苷酸合成中的偶联剂，并且特别适用于在肽合成中提高产率和抑制旋光异构化的偶联剂。还公开了一种制备这种亚胺型偶联剂的方法以及它们在多肽和/或多核苷酸制备中的用途。
• CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS
  申请人：TriLink BioTechnologies

  公开号：EP2451980B1

  公开（公告）日：2014-05-21
• Modified Diguanylate Cyclase-Phosphodiesterase and Method for Enzymatic Production of Cyclic-diGMP
  申请人：NESBITT Natasha M.

  公开号：US20140170689A1

  公开（公告）日：2014-06-19

  The present invention provides a recombinant polypeptide comprising a first portion and a second portion, wherein the sequence of the first portion is fully identical to amino acids 1 to 248 of the sequence set forth as SEQ ID NO:1 and the sequence of the second portion is other than amino acids 249 to 511 of the sequence set forth as SEQ ID NO:1.
• US8524898B2
  申请人：——

  公开号：US8524898B2

  公开（公告）日：2013-09-03
• US8728725B2
  申请人：——

  公开号：US8728725B2

  公开（公告）日：2014-05-20