(3R,6R)-6-allyl-3-ethyl-1-[(1S)-2-hydroxy-1-phenylethyl]piperidin-2-one | 1261298-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,6R)-6-allyl-3-ethyl-1-[(1S)-2-hydroxy-1-phenylethyl]piperidin-2-one
• 英文别名: (3R,6R)-3-ethyl-1-[(1S)-2-hydroxy-1-phenylethyl]-6-prop-2-enylpiperidin-2-one
• CAS: 1261298-21-8
• 化学式: C₁₈H₂₅NO₂
• 分子量: 287.402
• InChiKey: WZEXJIISFWGACE-HYVNUMGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3R,6R)-6-allyl-3-ethyl-1-[(1S)-2-hydroxy-1-phenylethyl]piperidin-2-one 在 氧气 、 sodium hydroxide 作用下， 以 甲基叔丁基醚 为溶剂， 反应 24.0h， 生成 (3R,6R)-6-allyl-3-ethylpiperidin-2-one 、 (3S,6R)-6-allyl-3-ethylpiperidin-2-one
  参考文献：
  名称：

  A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams

  摘要：

  Chiral non-racemic bicyclic lactams derived from phenylglycinol have been appointed as key building blocks for the preparation of enantiopure nitrogen compounds The removal of the chiral inductor leading to substituted piperidones by using air or oxygen in basic media is presented (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.09.014
• 作为产物：
  描述：

  (3S,6R,8aR)-6-ethyl-3-phenyl-2,3,6,7,8,8a-hexahydro-[1,3]oxazolo[3,2-a]pyridin-5-one 、 烯丙基三甲基硅烷 在 四氯化钛 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以91%的产率得到(3R,6R)-6-allyl-3-ethyl-1-[(1S)-2-hydroxy-1-phenylethyl]piperidin-2-one
  参考文献：
  名称：

  A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams

  摘要：

  Chiral non-racemic bicyclic lactams derived from phenylglycinol have been appointed as key building blocks for the preparation of enantiopure nitrogen compounds The removal of the chiral inductor leading to substituted piperidones by using air or oxygen in basic media is presented (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.09.014

文献信息

• A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams
  作者：Vladislav Semak、Carmen Escolano、Carlos Arróniz、Joan Bosch、Mercedes Amat

  DOI：10.1016/j.tetasy.2010.09.014

  日期：2010.10

  Chiral non-racemic bicyclic lactams derived from phenylglycinol have been appointed as key building blocks for the preparation of enantiopure nitrogen compounds The removal of the chiral inductor leading to substituted piperidones by using air or oxygen in basic media is presented (C) 2010 Elsevier Ltd All rights reserved