5-hydroxy-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-1,3 dihydrobenzimidazol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-hydroxy-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-1,3 dihydrobenzimidazol-2-one
• 英文别名: 5-Hydroxy-1-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-1,3-dihydro-benzimidazol-2-one；6-hydroxy-3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one
• 化学式: C₂₀H₂₁F₃N₄O₂
• 分子量: 406.408
• InChiKey: SPVGJCMHEPZYNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-methoxy-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydrobenzimidazol-2-one 在 氢溴酸 作用下， 以 水 为溶剂， 生成 5-hydroxy-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-1,3 dihydrobenzimidazol-2-one
  参考文献：
  名称：

  Benzimidazolone derivatives having mixed serotonin and dopamine receptors affinity

  摘要：

  通式（I）的化合物，其中R1、R2、R3和R4表示氢或羟基，但R1、R2、R3和R4不能同时表示氢，以及制备通式（I）化合物的方法和它们作为药物的用途。

  公开号：

  US06281218B1

文献信息

• Benzimidazolone derivatives having mixed serotonin and dopamine receptors affinity
  申请人：Ingelheim Italia S.p.A.

  公开号：US06281218B1

  公开（公告）日：2001-08-28

  Compounds of general formula (I) wherein R1, R2, R3, and R4 denote hydrogen or hydroxy with the proviso that R1, R2, R3, and R4 cannot simultaneously represent hydrogen, processes for their preparation of the compounds of general formula (I), and their use as pharmaceuticals.

  通式（I）的化合物，其中R1、R2、R3和R4表示氢或羟基，但R1、R2、R3和R4不能同时表示氢，以及制备通式（I）化合物的方法和它们作为药物的用途。
• Sexual desire enhancing medicaments comprising benzimidazolone derivatives
  申请人：Ceci Angelo

  公开号：US20070123540A1

  公开（公告）日：2007-05-31

  The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of sexual desire disorders.
• Benzimidazolone Derivatives For the Treatment of Premenstrual and Other Female Sexual Disorders
  申请人：Ceci Angelo

  公开号：US20080242679A1

  公开（公告）日：2008-10-02

  The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of premenstrual and other female sexual disorders.
• Benzimidazolone Derivatives for the Treatment of Urinary Incontinence
  申请人：Baiker Wolfgang

  公开号：US20090176698A1

  公开（公告）日：2009-07-09

  The invention relates to compositions comprising benzimidazolone derivatives of formula (I), optionally in form of the free base or in form of the pharmacologically acceptable acid addition salts thereof and methods of treating or preventing urinary incontinence, comprising the administration of a therapeutically effective amount of compound of formula (I), wherein R 1 , R 2 , R 3 , and R 4 denote hydrogen or hydroxy with the proviso that R 1 , R 2 , R 3 , and R 4 cannot simultaneously represent hydrogen, optionally in form of the free base or in form of the pharmacologically acceptable acid addition salts thereof.
• US6281218B1
  申请人：——

  公开号：US6281218B1

  公开（公告）日：2001-08-28