1-(4-ethoxyphenyl)-2-phenyl-3-piperidinopropan-1-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(4-ethoxyphenyl)-2-phenyl-3-piperidinopropan-1-ol
• 英文别名: 1-(4-ethoxyphenyl)-2-phenyl-3-piperidin-1-ylpropan-1-ol
• 化学式: C₂₂H₂₉NO₂
• 分子量: 339.478
• InChiKey: WUCDVUYSHKJRHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-ethoxyphenyl)-2-phenyl-3-piperidinopropan-1-ol 在 盐酸 作用下， 生成 1-(4-ethoxyphenyl)-2-phenyl-3-piperidinopropan-1-ol hydrochloride
  参考文献：
  名称：

  Synthesis and separation of diastereoisomeric 1-aryl-3-piperidino(morpholino)-2-phenylpropan-1-ols and their hydrochlorides

  摘要：

  1-Aryl-3-piperidino(morpholino)-2-phenylpropan-1-ols were synthesized by reduction of the corresponding 1-aryl-3-piperidino(morpholino)-2-phenylpropan-1-ones with lithium tetrahydridoaluminate, and the products were separated into erythro and threo isomers by fractional crystallization. Their relative configuration and diastereoisomeric purity was determined by H-1 NMR spectroscopy.

  DOI：

  10.1134/s1070428008090170
• 作为产物：
  描述：

  3-Piperidino-2-phenyl-1-(p-ethoxyphenyl)-propan-1-on 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 1-(4-ethoxyphenyl)-2-phenyl-3-piperidinopropan-1-ol 、 1-(4-ethoxyphenyl)-2-phenyl-3-piperidinopropan-1-ol
  参考文献：
  名称：

  Synthesis and separation of diastereoisomeric 1-aryl-3-piperidino(morpholino)-2-phenylpropan-1-ols and their hydrochlorides

  摘要：

  1-Aryl-3-piperidino(morpholino)-2-phenylpropan-1-ols were synthesized by reduction of the corresponding 1-aryl-3-piperidino(morpholino)-2-phenylpropan-1-ones with lithium tetrahydridoaluminate, and the products were separated into erythro and threo isomers by fractional crystallization. Their relative configuration and diastereoisomeric purity was determined by H-1 NMR spectroscopy.

  DOI：

  10.1134/s1070428008090170