Photobiotin | 96087-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: Photobiotin
• 英文别名: 5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[3-[3-(4-azido-2-nitroanilino)propyl-methylamino]propyl]pentanamide
• CAS: 96087-37-5
• 化学式: C23H35N9O4S
• 分子量: 533.6
• InChiKey: BRLRJZRHRJEWJY-JERZPMBSSA-N

物化性质

• 溶解度：
  H2O:10 mg/mL如果冷冻避光保存至少5 个月。

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  37
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  171
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  acetonitrile-water 、 4-二甲基氨基肉桂醛 、 D-生物素 、 、 、 、 Photobiotin 以 水 为溶剂， 生成 光生物素
  参考文献：
  名称：

  Compounds used as intermediates in the preparations of non-radioactive

  摘要：

  其中R.sub.1至R.sub.4，可以相同或不同，选择自H，1至5个碳原子的烷基，NO.sub.2，卤素，--COOH或--NH.sub.2的组；其中R.sub.5，R.sub.6，R.sub.7，R.sub.8，可以相同或不同，选择自H，1至5个碳原子的烷基和卤素的组；其中n为0至5的整数，m为1至10的整数，p为0至1的整数，a为0至1的整数，b为1至10的整数，如果a为1，则b为1，其中该基团##STR2##包括至少5个碳原子，D选择自##STR3##的组。该化合物可用作制备非放射性生物探针的中间体。

  公开号：

  US04898951A1

文献信息

• Lipid construct for delivery of insulin to a mammal
  申请人：SDG, INC.

  公开号：US10004686B2

  公开（公告）日：2018-06-26

  The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.

  本发明涉及一种肝细胞靶向组合物，该组合物包含与脂质构建物相关联的胰岛素，脂质构建物包括两性脂质和扩展两性脂质，该构建物可靶向肝细胞显示的受体。 该组合物可包括游离胰岛素和与复合物相关的胰岛素的混合物。 可以对组合物进行修饰，以保护胰岛素和复合物不被降解。 本发明还包括制造组合物、将胰岛素装入组合物以及回收组合物中各种成分的方法。 治疗糖尿病患者的方法。
• ENRICHING AND IDENTYFYING FETAL CELLS IN MATERNAL BLOOD FOR IN SITU HYBRIDIZATION
  申请人：APROGENEX, INC.

  公开号：EP0662152A1

  公开（公告）日：1995-07-12
• LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL
  申请人：SDG, Inc.

  公开号：EP1883394B1

  公开（公告）日：2018-03-28
• Supra molecular construct for delivery of interferon to a mammal
  申请人：Lau R. John

  公开号：US20070218117A1

  公开（公告）日：2007-09-20

  The instant invention is drawn to a hepatocyte targeted composition comprising interferon associated with a supra-molecular lipid construct comprising amphipathic lipid molecules and receptor binding molecule. The composition can comprise a mixture of free interferon and interferon associated with the complex. The composition can be modified to protect interferon and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading interferon into the composition and recycling various components of the composition. Methods of treating individuals infected with the hepatitis C and other hepatitis viruses.
• Orally bioavailable lipid-based constructs
  申请人：Lau John R.

  公开号：US20090087479A1

  公开（公告）日：2009-04-02

  The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapetucic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.