2-(2,4-Diamino-3-cyano-6-methoxy-10H-9-oxa-1-aza-anthracen-10-yl)-malononitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(2,4-Diamino-3-cyano-6-methoxy-10H-9-oxa-1-aza-anthracen-10-yl)-malononitrile
• 英文别名: 2-(2,4-diamino-3-cyano-7-methoxy-5H-chromeno[2,3-b]pyridin-5-yl)propanedinitrile
• 化学式: C₁₇H₁₂N₆O₂
• 分子量: 332.321
• InChiKey: HMXUFRLAIVAVBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-羟基-5-甲氧基苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 2-(2,4-Diamino-3-cyano-6-methoxy-10H-9-oxa-1-aza-anthracen-10-yl)-malononitrile
  参考文献：
  名称：

  Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported. © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.067

文献信息

• Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
  申请人：Pharmacia Corporation

  公开号：US20040127511A1

  公开（公告）日：2004-07-01

  Aminocyanopyridine compounds are described which are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2. Pharmaceutical compositions and kits are also described, which include an anminocyanopyridine MK-2 inhibiting compound.

  描述了能够抑制丝裂原活化蛋白激酶-2的氨基氰基吡啶化合物。还描述了包含氨基氰基吡啶MK-2抑制化合物的药物组合物和试剂盒。
• Method of making tricyclic aminocyanopyridine compounds
  申请人：Pharmacia Corporation

  公开号：US20040127714A1

  公开（公告）日：2004-07-01

  A method of making aminocyanopyridine compounds which are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 is described.

  本文描述了一种制备能够抑制有丝分裂原活化蛋白激酶-激活蛋白激酶-2的氨基氰吡啶化合物的方法。
• Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
  申请人：Pharmacia Corporation

  公开号：US20040127519A1

  公开（公告）日：2004-07-01

  A method is described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject in need of such inhibition, where the method involves administering to the subject an anminocyanopyridine MK-2 inhibiting compound, or a pharmaceutically acceptable salt thereof.

  本文描述了一种抑制需要抑制的受试者中的有丝分裂原活化蛋白激酶激活蛋白激酶-2的方法，其中该方法涉及向受试者给予一种抑制MK-2的氨基氰基吡啶化合物或其药学上可接受的盐。
• METHOD OF USING AMINOCYANOPYRIDINE COMPOUNDS AS MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS
  申请人：Pharmacia Corporation

  公开号：EP1569645A2

  公开（公告）日：2005-09-07
• METHOD OF MAKING TRICYCLIC AMINOCYANOPYRIDINE COMPOUNDS
  申请人：Pharmacia Corporation

  公开号：EP1569938A1

  公开（公告）日：2005-09-07