1-(4-羟苯基)哌嗪二氰溴化物

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(4-羟苯基)哌嗪二氰溴化物
• 中文别名: 4-1-哌嗪基)苯酚二氢溴酸盐；1-(4-羟苯基)-哌嗪二氢溴酸盐；4-哌嗪苯酚二氢溴化物
• 英文名称: hydron;4-piperazin-1-ylphenol;dibromide
• 化学式: C10H16Br2N2O
• mdl: MFCD00040816
• 分子量: 340.05
• InChiKey: IRGIAGAHMWSRKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.03
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.5
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 1-(4-羟苯基)哌嗪二氰溴化物 以72%的产率得到
  参考文献：
  名称：

  LIN, HAN-FEN;YUE, XIANG;CHEN, WEN-BIN, IYAO GUNE , 19,(1989) N, S. 75-76, 77

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4-Methoxyphenyl)piperazine-1,4-diium;dichloride 生成 1-(4-羟苯基)哌嗪二氰溴化物
  参考文献：
  名称：

  COMTE, MARIE-THERESE;MALLERON, JEAN-LUC;PEYRONEL, JEAN-FRANCOIS;TRUCHON, +

  摘要：

  DOI：

文献信息

• Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
  申请人：Janssen Pharmaceutica N.V.

  公开号：US04144346A1

  公开（公告）日：1979-03-13

  Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.

  1-(1,3-二氧杂环戊烷-2-基甲基)-1H-咪唑和1H-1,2,4-三唑可用作抗真菌和抗菌剂。
• Heterocyclic derivatives of
  申请人：Janssen Pharmaceutica N.V.

  公开号：US04402957A1

  公开（公告）日：1983-09-06

  Novel heterocyclic derivatives of [4-(piperazin-1-yl-phenoxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.

  新型杂环衍生物[4-(哌嗪-1-基-苯氧甲基)-1,3-二氧兰-2-基甲基]-1H-咪唑和1H-1,2,4-三唑，可用作抗真菌和抗菌剂。
• 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles
  申请人：Janssen Pharmaceutica N.V.

  公开号：US04223036A1

  公开（公告）日：1980-09-16

  Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.

  Novel 1-(1,3-二氧杂环戊烷-2-基) -1H-咪唑和1H-1,2,4-三唑可用作抗真菌和抗菌剂。
• Derivatives of (AZA)naphthalenesultam, their preparation and
  申请人：Rhone-Poulenc Sante

  公开号：US05021420A1

  公开（公告）日：1991-06-04

  This invention relates to a compound ##STR1## in which R.sub.1 represents a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or alkoxy radical, (c) a 3-indolyl radical, (d) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (e) a 3-(5-hydroxyindolyl) radical. a 1-piperazinyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by an alkoxy, alkyl, hydroxy, nitro or amino radical or a halogen atom, (c) a 1,2-benzisothiazol-3-yl radical, (d) a 1,2-benzisoxazol-3-yl radical or (e) a 2-pyridyl radical. a piperidino radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or a hydroxy, alkyl or alkoxy radical, (c) two phenyl radicals, (d) a bis(4-fluorophenyl)methylene radical, (e) a 4-fluorobenzoyl radical, (f) a 2-oxo-1-benzimidazolinyl radical, (g) a 2-oxo-1-benzimidazolinyl radical substituted in the 3-position by an alkylcarbonyl or benzoyl radical, (b) a hydroxy radical and a phenyl radical optionally substituted with an alkyl, alkoxy or hydroxy radical or a halogen atom, (i) a 3-indolyl radical, (j) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (k) a 3-(5-hydroxyindolyl) radical. either: R.sub.2 and R.sub.3, which are identical, represent a hydrogen or halogen atom and R.sub.4 represents a hydrogen atom or R.sub.2 and R.sub.4 represent a hydrogen atom and R.sub.3 represents a halogen atom or an acetylamino radical or R.sub.2 and R.sub.3 represent a hydrogen atom and R.sub.4 represents a halogen atom and R.sub.5 represents a --CH.dbd. group. or R.sub.2, R.sub.3 and R.sub.4 represent a hydrogen atom and R.sub.5 represents a nitrogen atom. R.sub.6 represents an alkylene chain containing 2 to 4 carbon atoms or a propylene chain substituted in the 1- or 3-position by an alkyl radical or in the 2-position by an alkyl, alkoxy, hydroxy, dialkylamino, piperidino, morpholino or thiomorpholino radical, with the reservation that when R.sub.6 represents a propylene radical substituted in the 2-position by a dialkylamino, piperidino, morpholino or thiomorpholino radical, R.sub.1 cannot be a radical containing a hydroxy radical, and their salts, are useful in therapy for their ability to block serotonin receptors.

  本发明涉及化合物##STR1## 其中R.sub.1代表1,2,3,6-四氢-1-吡啶基取代在4位上的基团，所述基团可以是(a)苯基基团，(b)被卤素原子或烷基、羟基或烷氧基取代的苯基基团，(c)3-吲哚基基团，(d)在氮原子上取代烷基或烷基羰基基团和/或在5位上取代卤素原子的3-吲哚基基团，或(e)3-(5-羟基吲哚基)基团；1-哌嗪基取代在4位上的基团，所述基团可以是(a)苯基基团，(b)被烷氧基、烷基、羟基、硝基或氨基基团或卤素原子取代的苯基基团，(c)1,2-苯并异噻唑-3-基基团，(d)1,2-苯并异恶唑-3-基基团或(e)2-吡啶基基团；取代在4位的哌啶基基团，所述基团可以是(a)苯基基团，(b)被卤素原子或羟基、烷基或烷氧基取代的苯基基团，(c)两个苯基基团，(d)双(4-氟苯基)亚甲基基团，(e)4-氟苯甲酰基基团，(f)2-氧代-1-苯并咪唑啉基团，(g)在3位上取代烷基羰基或苯甲酰基基团的2-氧代-1-苯并咪唑啉基团，(h)羟基基团和一个苯基基团，所述苯基基团可以选择取代烷基、烷氧基或羟基基团或卤素原子，(i)3-吲哚基基团，(j)在氮原子上取代烷基或烷基羰基基团和/或在5位上取代卤素原子的3-吲哚基基团，或(k)3-(5-羟基吲哚基)基团。R.sub.2和R.sub.3相同，分别代表氢原子或卤素原子，R.sub.4代表氢原子，或者R.sub.2和R.sub.4代表氢原子，R.sub.3代表卤素原子或乙酰氨基基团，或者R.sub.2和R.sub.3代表氢原子，R.sub.4代表卤素原子，R.sub.5代表--CH.dbd.基团，或者R.sub.2、R.sub.3和R.sub.4代表氢原子，R.sub.5代表氮原子。R.sub.6代表含有2到4个碳原子的烷基链或在1位或3位上取代烷基基团或在2位上取代烷基、烷氧基、羟基、二烷基氨基、哌啶基、吗啉基或硫代吗啉基的丙烯基链，但当R.sub.6代表在2位上取代二烷基氨基、哌啶基、吗啉基或硫代吗啉基的丙烯基链时，R.sub.1不能是含有羟基基团的基团。这些化合物及其盐在治疗中具有阻断血清素受体的能力。
• Derivatives of
  申请人：Janssen Pharmaceutica, N.V.

  公开号：US04503055A1

  公开（公告）日：1985-03-05

  Novel derivatives of 4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.

  新型衍生物4-(哌嗪-1-基-苯氧甲基)-1,3-二氧杂环戊烷-2-甲基-1H-咪唑和1H-1,2,4-三唑，可用作抗真菌和抗菌剂。