1-(8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-pyrrolidine; hydrobromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-pyrrolidine; hydrobromide
• 英文别名: 1-[(8-Chloro-5-methoxy-3,4-dihydronaphthalen-2-yl)methyl]pyrrolidine;hydrobromide；1-[(8-chloro-5-methoxy-3,4-dihydronaphthalen-2-yl)methyl]pyrrolidine;hydrobromide
• 化学式: BrH*C₁₆H₂₀ClNO
• 分子量: 358.706
• InChiKey: BJVWNNDGSZQQSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.35
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-pyrrolidine; hydrobromide 在 碳酸氢钠 、 氯甲酸苯酯 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 (8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-dimethyl-amine
  参考文献：
  名称：

  Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes

  摘要：

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.

  DOI：

  10.1021/jm00201a004

文献信息

• Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes
  作者：Willard M. Welch、J. J. Plattner、Wilford P. Stratten、C. A. Harbert

  DOI：10.1021/jm00201a004

  日期：1978.3

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.