1-<2-(N,N-Dimethylamino)ethyl>-3-ethylurea | 62594-29-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1-<2-(N,N-Dimethylamino)ethyl>-3-ethylurea
• 英文别名: Urea, N-[2-(dimethylamino)ethyl]-N'-ethyl-；1-[2-(dimethylamino)ethyl]-3-ethylurea
• CAS: 62594-29-0
• 化学式: C₇H₁₇N₃O
• 分子量: 159.231
• InChiKey: KVZNSCWDFPBNTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-<2-(N,N-Dimethylamino)ethyl>-3-ethylurea 在 亚硝酸丁酯 、 溶剂黄146 作用下， 以 乙醚 为溶剂， 反应 168.0h， 以57%的产率得到1-Nitroso-1-<2-(N,N-dimethylamino)ethyl>-3-ethylurea nitrite salt
  参考文献：
  名称：

  Saavedra, Joseph E.; Farnsworth, David W., Organic Preparations and Procedures International, 1992, vol. 24, # 6, p. 655 - 660

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基乙二胺 、 异氰酸乙酯 以 二氯甲烷 为溶剂， 生成 1-<2-(N,N-Dimethylamino)ethyl>-3-ethylurea
  参考文献：
  名称：

  Saavedra, Joseph E.; Farnsworth, David W., Organic Preparations and Procedures International, 1992, vol. 24, # 6, p. 655 - 660

  摘要：

  DOI：

文献信息

• [EN] BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS<br/>[FR] LIPIDES BIODÉGRADABLES POUR L'ADMINISTRATION D'AGENTS ACTIFS
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2013086354A1

  公开（公告）日：2013-06-13

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，其中在阳离子脂质的脂质部分（例如，疏水链）中具有一个或多个可生物降解的基团。这些阳离子脂质可以掺入脂质粒子中，用于递送一种活性剂，例如核酸。本发明还涉及包含中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选的甾醇的脂质粒子。脂质粒子还可以进一步包括治疗剂，例如核酸。
• [EN] BRANCHED ALKYL AND CYCLOALKYL TERMINATED BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS<br/>[FR] LIPIDES BIODÉGRADABLES RAMIFIÉS À TERMINAISONS ALKYLE ET CYCLOALKYLE DESTINÉS À L'ADMINISTRATION D'AGENTS ACTIFS
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2013086322A1

  公开（公告）日：2013-06-13

  The present invention relates to a cationic lipid of formula (I) having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及具有一个或多个生物可降解基团的阳离子脂质的化学式(I)，所述生物可降解基团位于阳离子脂质的脂质部分（例如，疏水链）中。这些阳离子脂质可以被纳入脂质粒子中，用于传递活性剂，例如核酸。该发明还涉及包括中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选地固醇的脂质粒子。脂质粒子还可以进一步包括治疗剂，例如核酸。
• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20160009637A1

  公开（公告）日：2016-01-14

  The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，其具有位于脂质基团（例如，疏水链）的中部或远端部位的一个或多个可生物降解的基团。这些阳离子脂质可以被纳入脂质颗粒中，用于传递活性剂，例如核酸。该发明还涉及包括中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选地固醇的脂质颗粒。脂质颗粒还可以进一步包含治疗剂，如核酸。
• Thiadiazoline derivative
  申请人：Murakata Chikara

  公开号：US20070112044A1

  公开（公告）日：2007-05-17

  An antitumor agent comprising a thiadiazoline derivative represented by the general formula (I), or a pharmacologically acceptable salt thereof as an active ingredient: (wherein Z represents a sulfur atom and the like, R 1 represents substituted or unsubstituted lower alkynyl and the like, R 2 represents a hydrogen atom and the like, R 3 represents substituted or unsubstituted lower alkyl and the like, and R 4 represents substituted or unsubstituted aryl and the like), and the like are provided.

  一种抗肿瘤剂，包括由通式（I）表示的噻二唑衍生物或其药学上可接受的盐作为活性成分：（其中Z代表硫原子等，R1代表取代或未取代的较低炔基等，R2代表氢原子等，R3代表取代或未取代的较低烷基等，R4代表取代或未取代的芳基等）等。
• Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4
  申请人：Tomperi Jussi

  公开号：US20100048549A1

  公开（公告）日：2010-02-25

  The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1, R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes sst 1 and/or sst 4 and can be used for the treatment or diagnosis of diseases or conditions wherein sst 1 and/or sst 4 agonists or antagonists are indicated to be useful.

  本发明涉及公式（I）中基于（杂）芳基磺酰氨基的肽类类似物，其中A，D，E，J，Q1，R1，R2，R3，p和j如所述定义，或其药学上可接受的盐或酯。公式（I）化合物具有对生长抑素受体亚型sst1和/或sst4的高亲和力和选择性，并可用于治疗或诊断sst1和/或sst4激动剂或拮抗剂被认为有用的疾病或情况。