1-(4-Fluoro-benzyl)-4-pyridin-2-yl-piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(4-Fluoro-benzyl)-4-pyridin-2-yl-piperazine
• 英文别名: 1-(4-Fluorobenzyl)-4-(pyridin-2-yl)piperazine；1-[(4-fluorophenyl)methyl]-4-pyridin-2-ylpiperazine
• 化学式: C₁₆H₁₈FN₃
• 分子量: 271.337
• InChiKey: JGEKGUAOLHEKFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-吡啶基)哌嗪 、 4-氟溴苄 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 1-(4-Fluoro-benzyl)-4-pyridin-2-yl-piperazine
  参考文献：
  名称：

  Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis

  摘要：

  A general fluorous thiol quenching method is introduced. Excess alpha-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00209-0

文献信息

• Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis
  作者：Wei Zhang、Dennis P Curran、Christine Hiu-Tung Chen

  DOI：10.1016/s0040-4020(02)00209-0

  日期：2002.5

  A general fluorous thiol quenching method is introduced. Excess alpha-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel. (C) 2002 Elsevier Science Ltd. All rights reserved.