2H-喹嗪,1,3,4,6,7,9a-六氢- | 1004-90-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 中文名称: 2H-喹嗪,1,3,4,6,7,9a-六氢-
• 英文名称: (+/-)-1,3,4,6,7,9a-Hexahydro-2H-chinolizin
• 英文别名: 1,3,4,6,7,9a-hexahydro-2H-quinolizine；(+/-)-1,3,4,6,7,9a-hexahydro-2H-quinolizin；1,3,4,6,7,9a-Hexahydro-2H-quinolizine；2,3,4,6,7,9a-hexahydro-1H-quinolizine
• CAS: 1004-90-6
• 化学式: C₉H₁₅N
• 分子量: 137.225
• InChiKey: QOSLIXYQUYOILJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2H-喹嗪,1,3,4,6,7,9a-六氢- 、 碘甲烷 生成 (5R,9aR)-5-methyl-2,3,4,6,7,9a-hexahydro-1H-quinolizin-5-ium;iodide
  参考文献：
  名称：

  FUJI T.; NOHARA M.; MITSUKUCHI M.; OHBA M.; SHIKATA K.; YOSHIFUGI S.; IKE+, CHEM. AND PHARM. BULL. , 1975, 23, NO 1, 144-156

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Acetoxyquinolizidine 生成 2H-喹嗪,1,3,4,6,7,9a-六氢-
  参考文献：
  名称：

  Unsaturated Amines. II. Determination of the Proximity of Nitrogen to a Double Bond by Ultraviolet Absorption Spectra¹

  摘要：

  DOI：

  10.1021/ja01607a064

文献信息

• USE OF SUBSTITUTED 1-(ARYL ETHYNYL)-, 1-(HETEROARYL ETHYNYL)-, 1-(HETEROCYCLYL ETHYNYL)- AND 1-(CYCLOALKENYL ETHYNYL)-CYCLOHEXANOLS AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150305334A1

  公开（公告）日：2015-10-29

  The invention relates to the use of substituted 1-(arylethynyl)-, 1-(heteroarylethynyl)-, 1-(heterocyclylethynyl)- and 1-(cycloalkenylethynyl)cyclohexanols or salts thereof where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiotic stress and/or for increasing plant yield.

  本发明涉及使用取代的1-(芳基乙炔基)-、1-(杂芳基乙炔基)-、1-(杂环基乙炔基)-和1-(环烯基乙炔基)环己醇或其盐，其中通式(I)中的基团与描述中给定的定义相对应，用于增强植物对非生物胁迫的耐受性和/或增加植物产量。
• Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments
  申请人：Merce Vidal Ramon

  公开号：US20090005417A1

  公开（公告）日：2009-01-01

  The present invention relates to substituted indazolyl sulfonamide and 2,3-dihydroindolyl sulfonamide compounds of general formula I, a process for their preparation, medicaments comprising said substituted indazolyl sulfonamide and 2,3-dihydro-indolyl sulfonamide compounds as well as the use of said substituted indazolyl sulfonamide and 2,3-dihydro-indolyl sulfonamide compounds for the preparation of medicaments, which are particularly suitable for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT 6 receptors.

  本发明涉及一般式I的取代的吲唑磺酰胺和2,3-二氢吲哚磺酰胺化合物，以及它们的制备方法、包含所述取代的吲唑磺酰胺和2,3-二氢吲哚磺酰胺化合物的药物，以及利用所述取代的吲唑磺酰胺和2,3-二氢吲哚磺酰胺化合物制备药物，特别适用于预防和/或治疗通过5-HT6受体介导的至少部分疾病或疾病的用途。
• Substituted hexahydroarylquinolizines
  申请人：Merck & Co., Inc.

  公开号：EP0259092A1

  公开（公告）日：1988-03-09

  Certain substituted hexahydroarylquinoli­zines and pharmaceutically acceptable salts thereof are peripherally selective α₂-adrenoceptor antagonists. The compounds are adapted to be employed for the treatment of certain pathological disorders such as hypertension, diabetes, disorders involving platelet aggregation and the like without side effects attributable to effect on the central nervous system.

  某些取代的六氢芳基喹嗪类化合物及其药学上可接受的盐类是外周选择性 α₂-肾上腺素受体拮抗剂。这些化合物可用于治疗某些病理紊乱，如高血压、糖尿病、血小板聚集紊乱等，且不会对中枢神经系统产生副作用。
• METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1028716A1

  公开（公告）日：2000-08-23
• Combination of NMDA-Receptor Ligand and a Compound With 5-HT6 Receptor Affinity
  申请人：Buschmann Helmut Heinrich

  公开号：US20100074955A1

  公开（公告）日：2010-03-25

  The present invention relates to an active substance combination comprising at least one compound with 5-HT 6 receptor affinity, and at least NMDA-receptor ligand, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.