3-Butyl-tetramethylensulfon | 71053-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 3-Butyl-tetramethylensulfon
• 英文别名: 3-n-Butylthiolane, S,S-dioxide；3-butylthiolane 1,1-dioxide
• CAS: 71053-05-9
• 化学式: C₈H₁₆O₂S
• 分子量: 176.28
• InChiKey: JEIQEQBAZNCTKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(n-butyl)tetrahydrothiophene 、 双氧水 以100%的产率得到
  参考文献：
  名称：

  VOLYNSKIJ N. P.; SHCHERBAKOVA L. P., IZV. AN CCCP. CEP. XIM., 1979, HO 5, 1080-1085

  摘要：

  DOI：

文献信息

• Method for producing tertiary butyl alcohol
  申请人：Koizumi Atsushi

  公开号：US20070010697A1

  公开（公告）日：2007-01-11

  The present invention provides a method for producing a tertiary butyl alcohol with a high reaction rate of hydration of isobutylene. Furthermore, the present invention provides a method for producing a tertiary butyl alcohol with a high reaction rate of hydration of isobutylene even in the case of using an isobutylene of low concentration as a raw material. In this method, a tertiary butyl alcohol is produced from isobutylene and water in the presence of a cation-exchange resin catalyst and at least one solvent selected from the group consisting of sulfones and organic carboxylic acids by using a catalytic distillation apparatus. The solvent to be used in the method for producing a tertiary butyl alcohol is preferably sulfolane, dimethyl sulfone or acetic acid.

  本发明提供了一种生产具有异丁烯水合反应速率高的三丁醇的方法。此外，本发明还提供了一种即使在使用低浓度异丁烯作为原料的情况下，仍能以高反应速率水合异丁烯生产三丁醇的方法。在这种方法中，利用阳离子交换树脂催化剂和从砜和有机羧酸组成的群体中选择的至少一种溶剂，在催化蒸馏设备中从异丁烯和水中生产三丁醇。用于生产三丁醇的方法中最好使用的溶剂是砜、二甲基砜或乙酸。
• Furopyridine compounds and uses thereof
  申请人：BARNES David

  公开号：US20120015907A1

  公开（公告）日：2012-01-19

  The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物I的公式；一种制造本发明化合物的方法及其治疗用途。本发明还提供了具有药理活性剂的组合物和制药组合物。
• PKM2 MODULATORS AND METHODS FOR THEIR USE
  申请人：TOLERO PHARMACEUTICALS, INC.

  公开号：US20150344436A1

  公开（公告）日：2015-12-03

  Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明揭示了具有PKM2激活剂活性的化合物。该化合物具有以下结构（I）：包括立体异构体、互变异构体、药学上可接受的盐和其前药，其中R1、R2、R3、R4、R5和R6如本文所定义。本发明还揭示了与制备和使用这种化合物相关的方法，以及包含这种化合物的制药组合物。
• A process for the preparation of an olefinically unsaturated ether
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0025240A1

  公开（公告）日：1981-03-18

  A process for the preparation of an olefinically unsaturated ether by reacting a conjugated diene and a lower alkanol with the aid of an acidic catalyst, in which process a non-basic aprotic polar solvent, such as methyl ethylketone or sulfolane, is used in order to increase the selectivity. As conjugated diene butadiene is preferred. Butadiene may be used together with isobutene, n-butenes and butanes.

  在酸性催化剂的帮助下，通过共轭二烯和低级烷醇反应制备烯烃不饱和醚的工艺，在该工艺中，为了提高选择性，使用了非碱性非烷基极性溶剂，如甲基乙基酮或砜。作为共轭二烯，丁二烯是首选。丁二烯可与异丁烯、正丁烯和丁烷一起使用。
• Process for the carbonylation of alkanols and/or ethers
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0042633A1

  公开（公告）日：1981-12-30

  Process forthe carbonylation of alkanols and/or ethers at elevated temperature and pressure in the presence of a Group VIII metal compound and pentachlorobenzenethiol and/or salts thereof, using a pentachlorobenzenethiol compound : Group VIII metal compound molar ratio of not more than 10. The process is of special interest for the production of methyl acetate from methanol using an active, iodine-free catalytic system.

  在第八族金属化合物和五氯苯硫酚和/或其盐存在下，在高温高压下对烷 醇和/或醚进行羰基化的工艺，使用的五氯苯硫酚化合物：第八族金属化合物摩尔比不超过 10。该工艺特别适用于使用活性无碘催化体系从甲醇中生产醋酸甲酯。