申请人:Tolero Pharmaceuticals, Inc.
公开号:US20170015631A1
公开(公告)日:2017-01-19
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I):
including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R
1
, R
2
, R
3
, R
4
, R
5
and R
6
are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.