Acetic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Acetic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester
• 英文别名: Acetic acid (3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl) ester；(3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl) acetate
• 化学式: C₂₀H₂₆O₃
• 分子量: 314.425
• InChiKey: QAHOQNJVHDHYRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Estradiol, diacetate 以82%的产率得到
  参考文献：
  名称：

  ONO, MITSUNORI;ITOH, ISAMU, TETRAHEDRON LETT., 30,(1989) N, C. 207-210

  摘要：

  DOI：

文献信息

• [EN] GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING GLUCOCORTICOID RECEPTOR ACTIVITY<br/>[FR] PEPTIDES DE LA SUPERFAMILLE DU GLUCAGON PRÉSENTANT UNE ACTION SUR LES RÉCEPTEURS AUX GLUCOCORTICOÏDES
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2013074910A1

  公开（公告）日：2013-05-23

  Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.

  本文提供了与GR配体结合的葡萄糖素超家族肽，这些肽能够作用于糖皮质激素受体。本文还提供了该发明的结合物的药物组合物和工具包。此外，本文还提供了治疗疾病的方法，例如代谢紊乱，如糖尿病和肥胖，包括给予该发明的结合物。
• Process for the Preparation of Phenolic Hydroxy-Substituted Compounds
  申请人：Vass Andras

  公开号：US20080039643A1

  公开（公告）日：2008-02-14

  The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae R 1 stands for straight chain or branched C 1-6 alkyl group; R 2 , R 3 , R 4 , R 5 , and R 6 have the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, C 1-6 alkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or R 2 and R 3 together stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or C 1-6 alkylcarbonyloxy group in the 17 position.

  本发明涉及一种制备羟基取代酚类化合物的方法，其通式为(I)，通过使用硫脲/氯化铝试剂对通式(II)的烷基芳基醚进行脱烷基化处理，其中，通式中R1代表直链或支链C1-6烷基；R2、R3、R4、R5和R6具有相同或不同的含义，代表氢原子或卤素原子、羟基、羧基、硝基、氧代、C1-6烷基羰基、直链或支链烷基或-烷氧基或芳基基团，或R2和R3共同代表一个5-7成员环或融合环系统；所述5-7成员环可以是一个部分饱和的环，可选地取代有一个氧代基，或者可以是一个不饱和的环；或者所述融合环系统可以与第一个环构成一种类固醇，优选为一种17位置可选地取代有氧代或C1-6烷基羰氧基的雌三烯衍生物。
• GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY
  申请人：Indiana University Research and Technology Corporation

  公开号：EP2569000B1

  公开（公告）日：2017-09-27
• GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING GLUCOCORTICOID RECEPTOR ACTIVITY
  申请人：Indiana University Research and Technology Corporation

  公开号：EP2780031B1

  公开（公告）日：2018-03-07
• Glucagon Superfamily Peptides Exhibiting Glucocorticoid Receptor Activity
  申请人：Indiana University Research and Technology Corp

  公开号：US20130157934A1

  公开（公告）日：2013-06-20

  Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.