N-ethyl-naphthalene-2-sulfonamide | 71862-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-ethyl-naphthalene-2-sulfonamide
• 英文别名: N-Aethyl-naphthalin-2-sulfonamid；N-ethylnaphthalene-2-sulfonamide
• CAS: 71862-50-5
• 化学式: C₁₂H₁₃NO₂S
• mdl: MFCD04553729
• 分子量: 235.307
• InChiKey: DDANNVJWHXFIDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙胺 、 2-萘磺酰氯 生成 N-ethyl-naphthalene-2-sulfonamide
  参考文献：
  名称：

  Carleson, Bulletin de la Societe Chimique de France, 1877, vol. <2>27, p. 360

  摘要：

  DOI：

文献信息

• Sulfonamide derivatives as ppar modulators
  申请人：Conner Eugene Scott

  公开号：US20060217433A1

  公开（公告）日：2006-09-28

  The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

  本发明涉及一种式（I）化合物：及其药学上可接受的盐、溶液剂、水合物或立体异构体，可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的疾病，如 X 综合征、II 型糖尿病、高血糖、高脂血症、肥胖、凝血功能障碍、高血压、动脉硬化以及其他与 X 综合征和心血管疾病相关的疾病。
• SULFONAMIDE DERIVATIVES AS PPAR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1597248A2

  公开（公告）日：2005-11-23
• FILAMIN A-BINDING ANTI-INFLAMMATORY ANALGESIC
  申请人：Burns Barbier Lindsay

  公开号：US20110105484A1

  公开（公告）日：2011-05-05

  A compound, its pharmaceutically acceptable salt, a composition containing the same and method of treatment that can provide analgesia and/or reduce inflammation are disclosed. A contemplated compound has a structure that corresponds to Formula A, wherein G, W, Q, Z, D, E, F, K, Y, d, e, f, k, n, m, and circle B and all R groups are defined within.
• FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC
  申请人：Burns Barbier Lindsay

  公开号：US20110105481A1

  公开（公告）日：2011-05-05

  A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within.
• US5385925A
  申请人：——

  公开号：US5385925A

  公开（公告）日：1995-01-31