十二烷氢-1,4,7,9b-四氮杂萘并苯 | 10553-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 十二烷氢-1,4,7,9b-四氮杂萘并苯
• 中文别名: 十二氢-1,4,7,9beta-四偶氮非那烯
• 英文名称: Dodecahydro-1,4,7,9b-tetraaza-phenalen
• 英文别名: dodecahydro-1,4,7,9b-tetraazaphenalene；2,6,10,13-tetrazatricyclo[7.3.1.05,13]tridecane
• CAS: 10553-85-2
• 化学式: C₉H₁₈N₄
• mdl: MFCD00047650
• 分子量: 182.269
• InChiKey: ZNJURNUHQCGRLX-UHFFFAOYSA-N

物化性质

• 熔点：
  118-120 °C(Solv: carbon tetrachloride (56-23-5))
• 沸点：
  110 °C(Press: 0.1 Torr)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  39.3
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2912299000

反应信息

• 作为反应物：
  描述：

  十二烷氢-1,4,7,9b-四氮杂萘并苯 在 palladium on activated charcoal 作用下， 以 xylene 为溶剂， 反应 48.0h， 以2.3%的产率得到1,4,7-triazacycl<3.3.3>azine
  参考文献：
  名称：

  1,4,7-Triazacycl[3.3.3]azine: basicity, photoelectron spectrum, photophysical properties

  摘要：

  DOI：

  10.1021/ja00261a004

文献信息

• Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
  申请人：Altenbach J. Robert

  公开号：US20050272736A1

  公开（公告）日：2005-12-08

  Compounds of formula (I) wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X′, Y, Y′, Z, and Z′ are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

  式（I）中R1或R2为含有至少两个杂原子的三环或二环环，其中R1、R2、R3、R3a、R3b、R4、R5、L、X、X′、Y、Y′、Z和Z′如本文所定义，在预防或改善组织胺-3受体配体引起的病症或紊乱方面具有治疗作用。还公开了包含组织胺-3受体配体的药物组合物，使用这类化合物和组合物的方法，以及制备符合式（I）范围内化合物的过程。
• Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands
  申请人：Altenbach J. Robert

  公开号：US20050256309A1

  公开（公告）日：2005-11-17

  Compounds of formula (I) wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X′, Y, Y′, Z, and Z′ are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

  式（I）中R1或R2为含有至少两个杂原子的三环或二环环，其中R1、R2、R3、R3a、R3b、R4、R5、L、X、X′、Y、Y′、Z和Z′如本文所定义，在预防或改善组织胺-3受体配体引起的病症或紊乱方面具有治疗作用。还公开了包含组织胺-3受体配体的药物组合物，使用这类化合物和组合物的方法，以及制备符合式（I）范围内化合物的方法。
• Polyurethane foams prepared from condensation products of amines, epihalohydrins and alkylene oxides
  申请人：BASF WYANDOTTE CORPORATION

  公开号：EP0008307A1

  公开（公告）日：1980-03-05

  Oxyalkylated condensation products prepared from aliphatic and aromatic amines, epihalohydrin and alkylene oxides are used in the preparation of polyurethane foams.

  由脂肪胺和芳香胺、表卤代醇和氧化亚烷基制备的氧烷基缩合产品可用于制备聚氨酯泡沫。
• TRI- AND BI-CYCLIC HETEROARYL HISTAMINE-3 RECEPTOR LIGANDS
  申请人：ABBOTT LABORATORIES

  公开号：EP1751130A2

  公开（公告）日：2007-02-14
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS
  申请人：Dunn William A.

  公开号：US20120141491A1

  公开（公告）日：2012-06-07

  The subject application provides small compounds that are able to increase/enhance autophagy in various cells. These compounds are useful in augmenting existing treatments of various cancers, microbial/viral infections, and neurodegenerative diseases. Thus, the subject application also provides methods of treating various types of cancers, microbial/viral infections, and neurodegenerative diseases.