Ammonium iron(ii)sulfate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 英文名称: Ammonium iron(ii)sulfate
• 英文别名: azane;hydrogen sulfate;iron(2+)
• 化学式: FeH8N2O8S2
• 分子量: 284.1
• InChiKey: IMBKASBLAKCLEM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.93
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  179
• 氢给体数：
  2
• 氢受体数：
  8

ADMET

毒理性

• 副作用

职业性肝毒素 - 次级肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

保持呼吸道畅通，必要时协助通气。积极使用静脉晶体液治疗由出血性胃肠炎引起的休克，并在需要时输血。由于胃肠道丢失和液体转移到肠壁和间质空间，患者常常出现明显的低血容量。如果出现昏迷、惊厥和代谢性酸中毒，则进行治疗。对于严重中毒的患者（例如，休克、严重酸中毒和/或血清铁> 500-600 mcg/dL），给予去铁胺。监测尿液，以发现特征性的橙红色去铁胺-铁复合物。当尿液恢复正常或血清铁水平降至正常范围时，可以停止治疗。长期使用去铁胺与成人呼吸窘迫综合征和耶尔森菌血症有关。

Maintain an open airway and assist ventilation if necessary. Treat shock caused by hemorrhagic gastrointestinitis aggressively with intravenous crystalloid fluids, and replace blood if needed. Patients are often markedly hypovolemic owing to gastrointestinal losses and third spacing of fluids into the intestinal wall and interstitial space. Treat coma, seizures, and metabolic acidosis if they occur. For seriously intoxicated victims (eg, shock, severe acidosis, and/or serum iron > 500-600 mcg/dL) administer deferoxamine. Monitor the urine for the urine for the characteristic orange or pink deferoxamine-iron complex. Therapy may be stopped when the urine returns to normal or when the serum iron level decreases to the normal range. Prolonged deferoxamine has been associated with adult respiratory distress syndrome and Yersinia sepsis.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

活性炭无效。不建议使用吐根糖浆，因为它可能加剧铁剂引起的胃肠道刺激，并干扰全肠道冲洗。如果产品是液体配方或片剂被咀嚼，考虑洗胃。不要使用含磷酸盐的溶液进行灌洗；这可能导致生命威胁性的高钠血症、高磷酸盐血症和低钙血症。碳酸氢盐和去铁胺灌洗的效果值得怀疑。去铁胺灌洗无效，并可能增强铁的吸收。全肠道冲洗对摄入的片剂非常有效，可以被视为一线治疗方法，特别是在普通腹部X光片上可见大量片剂的情况下。大量摄入可能导致凝结物或胃石。重复或长时间的全肠道冲洗可能去除片剂。内窥镜检查或外科胃切开术很少需要。

Activated charcoal is not effective. Ipecac is not recommended, because it can aggravate iron-induced gastrointestinal irritation and interfere with whole bowel irrigation. Consider gastric lavage if product was a liquid formulation or tablets were chewed. Do-not use phosphate-containing solutions for lavage; these may result in life-threatening hypernatremia, hyperphosphatemia, and hypocalcemia. Bicarbonate and deferoxamine lavage are of doubtful efficacy. Deferoxamine lavage is not effective and may enhance iron absorption. Whole-bowel irrigation is very effective for ingested tablets and may be considered first-line treatment, especially if large numbers of tablets are visible on plain abdominal x-ray. Massive ingestions may lead to concretions or bezoars. Repeated or prolonged whole-bowel irrigation may remove tablets. Endoscopy or surgical gastrotomy is rarely required.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

血液透析和血液灌流对于去除铁无效，但在去除肾衰竭患者体内的铁-去铁胺复合物时可能是必要的。交换输血偶尔用于大量儿童摄入，但其疗效值得怀疑。

Hemodialysis and hemoperfusion are not effective for removing iron but may be necessary to remove iron-deferoxamine complex in patients with renal failure. Exchange transfusion is occasionally used for massive pediatric ingestions but is of questionable efficacy.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并视必要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽，有强烈的干呕反射，且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。/铁及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

口服 Vitaferro 后，正常和贫血孕妇后半期以及非孕妇的铁药代动力学和生物利用度进行了描述。在所有孕妇中，该药物的生物利用度是非孕妇的两倍。消除参数表明，在怀孕期间铁的保留增加。该药物吸收良好，未引起不兼容性。

The pharmacokinetics and bioavailability of iron following the oral administration of Vitaferro to normal and anemic women in their second half of pregnancy and to nonpregnant women are described. In all pregnant probands the bioavailability of the drug was about twice as high as in nonpregnant women. The parameters of elimination refer to an enhanced retention of iron during pregnancy. The drug was well resorbed and did not cause incompatibilities.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  Ammonium iron(ii)sulfate 、 铁粉 、 Phosphoric Acid Dipotassium 、 、 、 ammonium hydroxide 、 在 磷酸亚铁 、 vivianite 作用下， 反应 0.26h， 生成 磷酸亚铁
  参考文献：
  名称：

  METHOD FOR PREPARING NANO-SIZED IRON PHOSPHATE PARTICLES

  摘要：

  本发明涉及一种制备纳米级磷酸铁颗粒的方法，该方法包括以下步骤：在反应器中混合铁盐溶液和磷酸盐溶液，以制备含有非晶态或晶态磷酸铁沉淀物的悬浮液；并在混合溶液内施加剪切力，以形成含有纳米级磷酸铁沉淀颗粒的悬浮液，通过剪切力和反应器内部条件形成。根据本发明，微观混合比核化更快，这为制备纳米颗粒和具有均匀粒径分布的颗粒提供了优势。

  公开号：

  US20150203354A1
• 作为试剂：
  描述：

  、 过氧化氢苯甲酰 、 过氧化苯甲酰 、 氯仿 在 sodium hydroxide 、 氯化钠 、 Ammonium iron(ii)sulfate 、 碳酸氢钠 、 Sodium sulfate-III 作用下， 反应 120.0h， 以to give 6.96 g (yield: 80%) 1,2-epoxy-4-(o-chlorophenyl)butane as a colorless liquid的产率得到1,2-epoxy-4-(o-chlorophenyl)butane
  参考文献：
  名称：

  5-Phenethyl-2-oxazolidone derivatives and a process for producing the

  摘要：

  具有以下式子的5-苄基噁唑酮化合物：##STR1## 其中R代表氢原子，卤素原子或低烷氧基。具有肌肉松弛、镇痛和抗炎活性。

  公开号：

  US04236012A1

文献信息

• Process for producing cobalt- and iron-containing ferromagnetic powder
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04066564A1

  公开（公告）日：1978-01-03

  A Co- and Fe-containing ferromagnetic iron oxide powder having a high coercive force and improved stability to heat and pressure is produced by adding an aqueous alkali solution, an aqueous solution containing Co.sup.+2 ions, and an aqueous solution containing not more than 1 equivalent, based on the Co.sup.+2 ions, of Fe ions to a suspension of ferromagnetic iron oxide, and heating the mixture at a temperature of at least 80.degree. C in the presence of an oxidizing agent. The ferromagnetic iron oxide powder is especially suitable for producing magnetic recording media.

  一种含有Co和Fe的铁氧体粉末，具有高的矫顽力和改善的耐热性和耐压性，通过向铁磁性铁氧体悬浮液中添加水溶性碱溶液、含Co.sup.+2离子的水溶液和不超过1当量的含Fe离子的水溶液，并在氧化剂存在下以至少80℃的温度加热混合物而制成。该铁氧体粉末特别适用于生产磁性记录介质。
• Process for producing ferromagnetic powder
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04069164A1

  公开（公告）日：1978-01-17

  In a process for producing ferromagnetic powder which comprises adding an aqueous solution containing Co.sup.+2 ions, with or without another cation or cations, and an alkali solution to a suspension of ferromagnetic iron oxide, and heating the mixture to produce ferromagnetic iron oxide containing the metal provided by such an ion (s), the improvement wherein the heating is carried out in the presence of an oxidizing agent.

  一种生产铁磁性粉末的方法，包括将含有Co.sup.+2离子的水溶液（带有其他阳离子或阳离子的情况下）和碱性溶液加入到铁磁性氧化铁的悬浮液中，并加热混合物以产生含有该离子提供的金属的铁磁性氧化铁，改进在于在存在氧化剂的情况下进行加热。
• Process for producing ferrogmagnetic iron oxide powder comprising a
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04125474A1

  公开（公告）日：1978-11-14

  In a process for producing a ferromagnetic powder having a high coercive force which comprises adding an aqueous solution containing Co.sup.+2 ions, or both Co.sup.+2 ions and another cation(s), and an alkali solution to a suspension of a ferromagnetic iron oxide containing the metal(s) given by these ion(s), the improvement wherein said ferromagnetic iron oxide is treated with a reducing agent prior to the preparation of the suspension.

  一种制备高矫顽力铁磁粉的方法，包括将含有Co.sup.+2离子或同时含有Co.sup.+2离子和其他阳离子的水溶液以及碱性溶液加入含有由这些离子给出的金属的铁磁性氧化铁悬浮液中，改进在制备悬浮液之前，先用还原剂处理所述铁磁性氧化铁。
• METHOD FOR PREPARING NANO-SIZED IRON PHOSPHATE PARTICLES
  申请人：SAMSUNG FINE CHEMICALS CO., LTD

  公开号：US20150203354A1

  公开（公告）日：2015-07-23

  The present invention relates to a method for preparing nano-sized iron phosphate particles, the method including the steps of: mixing an iron salt solution and a phosphate solution in a reactor in order to prepare a suspension containing amorphous or crystalline iron phosphate precipitate; and applying a shearing force to the mixed solution inside the reactor during the step of mixing, wherein the suspension containing nano-sized iron phosphate precipitate particles is formed by means of the shearing force and the conditions inside the reactor. According to the present invention, micro-mixing takes place faster than nucleation, which provides an advantage for preparing nanoparticles and for preparing particles having a uniform particle size distribution.

  本发明涉及一种制备纳米级磷酸铁颗粒的方法，该方法包括以下步骤：在反应器中混合铁盐溶液和磷酸盐溶液，以制备含有非晶态或晶态磷酸铁沉淀物的悬浮液；并在混合溶液内施加剪切力，以形成含有纳米级磷酸铁沉淀颗粒的悬浮液，通过剪切力和反应器内部条件形成。根据本发明，微观混合比核化更快，这为制备纳米颗粒和具有均匀粒径分布的颗粒提供了优势。