2,3-二氢-1,4-苯并噁嗪-2-甲胺盐酸盐 | 1446-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 中文名称: 2,3-二氢-1,4-苯并噁嗪-2-甲胺盐酸盐
• 中文别名: 2,3-二氢-1,4-苯并二氧-2-甲胺盐酸盐
• 英文名称: 2,3-Dihydro-1,4-Benzodioxin-2-methanamine hydrochloride
• 英文别名: 2,3-dihydro-1,4-benzodioxin-3-ylmethanamine;hydrochloride
• CAS: 1446-27-1
• 化学式: C9H12ClNO2
• mdl: MFCD01309162
• 分子量: 201.65
• InChiKey: QIPSWJFYYUTYHX-UHFFFAOYSA-N

物化性质

• 熔点：
  110 °C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0.75
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  46.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2,3-二氢-1,4-苯并噁嗪-2-甲胺盐酸盐 、 N-(2-tosyloxyethyl)-3,3-tetramethylene glutarimide 生成 比螺酮
  参考文献：
  名称：

  HIBERT, MARCEL

  摘要：

  DOI：

文献信息

• Indolealkyl derivatives of benzodioxanmethylamine
  申请人：American Home Products Corporation

  公开号：US05750724A1

  公开（公告）日：1998-05-12

  The compounds of formula I: ##STR1## wherein R.sup.1, R.sup.4 and R.sup.5 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido; or, R.sup.1 is defined as above and R.sup.4 and R.sup.5, taken together, are ortho substituted methylenedioxy, ethylenedioxy, or propylenedioxy; R.sup.2 and R.sup.3 are, independently, hydrogen or alkyl; n is 3 or 4; or pharmaceutically acceptable salts thereof, are useful in the treatment of depression and related disorders.

  式I的化合物：##STR1## 其中R.sup.1，R.sup.4和R.sup.5独立地表示氢，烷基，烷氧基，芳基烷氧基，烷酰氧基，羟基，卤素，三氟甲基，氨基，单烷基或双烷基氨基，烷基酰胺基或烷基磺酰胺基; 或者，R.sup.1如上所定义，而R.sup.4和R.sup.5在取代位上共同为邻位取代的亚甲氧基，乙二氧基或丙二氧基; R.sup.2和R.sup.3独立地表示氢或烷基; n为3或4; 或其药学上可接受的盐，在治疗抑郁症及相关疾病方面有用。
• INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0861248B1

  公开（公告）日：2001-12-12
• COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST
  申请人：Jin Peng

  公开号：US20120071539A1

  公开（公告）日：2012-03-22

  Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decrease) the level of the polynucleotide targeted by the silencing element. Methods of using such compositions both in therapies involving RNAi-mediated suppression of gene expression, as well as, in vitro methods that allow for the targeted modulation of expression of a polynucleotide of interest are provided. Pharmaceutical or cosmetic compositions comprising such compounds and silencing elements also are disclosed. Methods for screening a compound of interest for the ability to modulate the activity of a heterologous silencing element also are provided.
• US5424456A
  申请人：——

  公开号：US5424456A

  公开（公告）日：1995-06-13
• US5750724A
  申请人：——

  公开号：US5750724A

  公开（公告）日：1998-05-12