(R)-3-(acetoxy)-3-phenylpropanoic acid | 127675-73-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (R)-3-(acetoxy)-3-phenylpropanoic acid
• 英文别名: (R)-3-acetoxy-3-phenyl-propionic acid；(R)-3-Acetoxy-3-phenyl-propionsaeure；(3R)-3-acetyloxy-3-phenylpropanoic acid
• CAS: 127675-73-4
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: IPYPGJNFRFPOPW-SNVBAGLBSA-N

物化性质

• 沸点：
  335.6±30.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-3-(acetoxy)-3-phenylpropanoic acid 、 重氮甲烷 以15%的产率得到
  参考文献：
  名称：

  SANTANIELLO, ENZO;FERRABOSCHI, PATRIZIA;GRISENTI, PARIDE;MANZOCCHI, ADA;T+, GAZZ. CHIM. ITAL., 119,(1989) N1, C. 581-584

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 3-acetoxy-3-phenylpropionate 生成 (R)-3-(acetoxy)-3-phenylpropanoic acid
  参考文献：
  名称：

  SANTANIELLO, ENZO;FERRABOSCHI, PATRIZIA;GRISENTI, PARIDE;MANZOCCHI, ADA;T+, GAZZ. CHIM. ITAL., 119,(1989) N1, C. 581-584

  摘要：

  DOI：

文献信息

• Catalytic Asymmetric Vinylogous Mukaiyama-Aldol (CAVM) Reactions:  The Enolate Activation
  作者：Guillaume Bluet、Jean-Marc Campagne

  DOI：10.1021/jo015567s

  日期：2001.6.1

  The Catalytic Asymmetric Vinylogous Mukaiyama (CAVM) reactions of various aldehydes with dienolate 1 using different enolate activations (CuF*(S)-TolBinap, t-BuOCu*(S)-Tol-Binap, and various chiral nonracemic ammonium fluorides derived from cinchona alkaloids) are described. These reactions proved to be highly regioselective leading exclusively to the alpha-aldol products in good yields and poor to

  各种醛与二烯醇酯1的催化不对称Vinylogous Mukaiyama（CAVM）反应使用不同的烯醇盐活化（CuF *（S）-TolBinap，t-BuOCu *（S）-Tol-Binap和各种从金鸡纳生物碱衍生的手性非外消旋铵氟化物）进行了说明。这些反应被证明是高度区域选择性的，仅导致α-醛醇产物的产率高和对映选择性差或良好。
• Pulmonary cryptococcosis and Capillaria aerophila infection in an FIV-positive cat
  作者：VR BARRS、P. MARTIN、RG NICOLL、JA BEATTY、R. MALIK

  DOI：10.1111/j.1751-0813.2000.tb10581.x

  日期：2000.3

  A 12‐year‐old, FIV‐positive, domestic longhair cat was presented with a history of sneezing and coughing during the previous seven months. On thoracic radiographs, a prominent bronchial pattern and three focal, opacified nodules were seen. Cytology of bronchoalveolar lavage fluid demonstrated spherical, capsulate, narrow‐necked, budding yeasts within macrophages. Culture of the fluid yielded a heavy growth of Cryptococcus neoformans var neoformans. The serum latex cryptococcal antigen agglutination test titre was 158. The cat was treated with itraconazole and the cough resolved over a 5‐month period but then recurred. Repeat thoracic radiographs showed resolution of the pulmonary nodules but a persistent bronchial pattern. Adult nematodes and ova with morphology characteristic of Capillaria aerophila were seen in bronchoalveolar lavage fluid and no yeasts were cultured from the fluid. The cryptococcal titre was zero. The lungworm infection was treated successfully with abamectin and the cough resolved. Immunosuppression related to FIV infection may have predisposed this cat to sequential respiratory tract infections.