1-[1-(4-Chlorophenyl)-2-phenylethyl]-3-(2-hydroxyethyl)-thiourea | 858864-59-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[1-(4-Chlorophenyl)-2-phenylethyl]-3-(2-hydroxyethyl)-thiourea
• 英文别名: 1-[1-(4-chlorophenyl)-2-phenylethyl]-3-(2-hydroxyethyl)thiourea
• CAS: 858864-59-2
• 化学式: C₁₇H₁₉ClN₂OS
• 分子量: 334.87
• InChiKey: XBOCALWTMGAWKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[1-(4-Chlorophenyl)-2-phenylethyl]-3-(2-hydroxyethyl)-thiourea 在 盐酸 作用下， 以 水 为溶剂， 生成 1-[1-(4-chlorophenyl)-2-phenyl-ethyl]-(4,5-dihydrothiazol-2-yl)-amine
  参考文献：
  名称：

  [EN] 1-(AZOLIN-2-YL) AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATTING INSECTS, ARACHNIDS AND NEMATODES
  [FR] COMPOSES 1-(AZOLIN-2-YL) AMINO-1,2-DIPHENYLETHANE DESTINES A LA LUTTE CONTRE LES INSECTES, LES ARACHNIDES ET LES NEMATODES

  摘要：

  本发明涉及通式（I）的1-（噁唑啉-2-基）氨基-1,2-二苯乙烷化合物，其中A是式A'或A2的基团：NRA' A2，其中m为0、1、2、3、4或5，n为0、1、2、3、4或5，X为硫或氧，变量R1、R2、R3、R4、R5a、R5b、R5c、R5d如权利要求所定义，以及其农业上可接受的盐。本发明还涉及一种用于防治动物害虫的方法，所选害虫包括昆虫、蜘蛛和线虫，以及一种用于保护作物免受昆虫、蜘蛛或线虫的攻击或侵染的方法，其中包括将通式I的1-（噁唑啉-2-基）氨基-1,2-二苯乙烷化合物和/或至少一种其盐的杀虫剂有效量与作物接触。

  公开号：

  WO2005063724A1
• 作为产物：
  描述：

  1-Chloro-4-(1-isothiocyanato-2-phenylethyl)benzene 、 C.I.酸性橙108 在 silica 作用下， 以 氯仿 为溶剂， 反应 16.0h， 以Chromatography on silica yielded the product (0.30 g)的产率得到1-[1-(4-Chlorophenyl)-2-phenylethyl]-3-(2-hydroxyethyl)-thiourea
  参考文献：
  名称：

  1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating insects, arachnids and nematodes

  摘要：

  本发明涉及一般式(I)的1-(咪唑-2-基)氨基-1,2-二苯乙烷类化合物，其中A是式A′或A2的基团：N R A′ A2，其中m为0、1、2、3、4或5，n为0、1、2、3、4或5，X为硫或氧，变量R1、R2、R3、R4、R5a、R5b、R5c、R5d如权利要求所定义的，并且还包括其农业可接受的盐。本发明还涉及一种用于防治动物害虫（包括昆虫、蜘蛛和线虫）的方法，以及一种用于保护作物免受昆虫、蜘蛛或线虫的攻击或侵染的方法，其中包括将一般式I的1-(咪唑-2-基)氨基-1,2-二苯乙烷类化合物和/或至少一种其盐的杀虫剂有效量与作物接触。

  公开号：

  US20070149582A1

文献信息

• 1-(1,2 Diphenyl-Ethyl)-3-(2-Hydroxyethyl)-Thiourea Compounds For Combating Animal Pests
  申请人：Kordes Markus

  公开号：US20080161403A1

  公开（公告）日：2008-07-03

  The present invention relates to a method of combating animal pests which comprises contacting the animal pest, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation, with a pesticidally effective amount of at least one 1-(1,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compound I or an agriculturally acceptable salt thereof, wherein m is 0 to 5, n is 0 to 5, R 3 and R 4 are H or optionally substituted alkyl, haloalkyl, cycloalkyl, phenyl or benzyl, R 7 , R 8 , R 9 and R 10 are H or optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkylamino, C 1 -C 6 -alkoxy, C 3 -C 6 -cycloalkyl, phenyl or benzyl and the variables R 1 , R 2 , R 5 and R 6 are as defined in the claims. The invention relates also to a method for protecting crops from attack or infestation by animal pests, a method for protecting non-living materials from attack or infestation by animal pests, novel 1-(1,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compounds I and their agriculturally acceptable salts as well as to an agricultural composition comprising a 1-(1,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compound I or a salt thereof.

  本发明涉及一种对抗动物害虫的方法，该方法包括将至少一种1-(1,2-二苯基乙基)-3-(2-羟乙基)-硫脲化合物I或其农业可接受的盐的农药有效量与动物害虫、它们的习性、繁殖地、食物供应、植物、种子、土壤、区域、动物害虫正在生长或可能生长的环境或需要保护免受动物攻击或侵害的材料、植物、种子、土壤、表面或空间接触，其中m为0至5，n为0至5，R3和R4为H或可选择取代的烷基、卤代烷基、环烷基、苯基或苄基，R7、R8、R9和R10为H或可选择取代的C1-C6烷基、C1-C6卤代烷基、C1-C6烷基氨基、C1-C6烷氧基、C3-C6环烷基、苯基或苄基，变量R1、R2、R5和R6如权利要求所定义。本发明还涉及一种保护作物免受动物害虫攻击或侵害的方法，一种保护非生物材料免受动物害虫攻击或侵害的方法，新型1-(1,2-二苯基乙基)-3-(2-羟乙基)-硫脲化合物I及其农业可接受的盐，以及包含1-(1,2-二苯基乙基)-3-(2-羟乙基)-硫脲化合物I或其盐的农业组合物。
• 1-(AZOLIN-2-YL) AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATTING INSECTS, ARACHNIDS AND NEMATODES
  申请人：BASF SE

  公开号：EP1713786B1

  公开（公告）日：2012-08-08
• 1-(1,2-DIPHENYL-ETHYL)-3-(2-HYDROXYETHYL)-THIOUREA COMPOUNDS FOR COMBATING ANIMAL PESTS
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1890541A2

  公开（公告）日：2008-02-27
• US7655600B2
  申请人：——

  公开号：US7655600B2

  公开（公告）日：2010-02-02
• [EN] 1-(1,2-DIPHENYL-ETHYL)-3-(2-HYDROXYETHYL)-THIOUREA COMPOUNDS FOR COMBATING ANIMAL PESTS<br/>[FR] 1-(1,2-DIPHENYL-ETHYL)-3-(2-HYDROXYETHYL)-THIOUREA COMPOUNDS FOR COMBATING ANIMAL PESTS
  申请人：BASF AG

  公开号：WO2006125745A2

  公开（公告）日：2006-11-30

  [EN] The present invention relates to a method of combating animal pests which comprises contacting the animal pest, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal at- tack or infestation, with a pesticidally effective amount of at least one 1-(1 ,2-diphenyl- ethyl)-3-(2-hydroxyethyl)-thiourea compound I or an agriculturally acceptable salt thereof, wherein m is 0 to 5, n is 0 to 5, R³ and R⁴ are H or optionally substituted alkyl, haloalkyl, cycloalkyl, phenyl or benzyl, R⁷, R⁸, R⁹ and R¹⁰ are H or optionally substituted C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆- alkylamino, C₁-C₆-alkoxy, C₃-C₆-cycloalkyl, phenyl or benzyl and the variables R¹, R², R⁵ and R⁶ are as defined in the claims. The invention relates also to a method for protecting crops from attack or infestation by animal pests, a method for protecting non-living materials from attack or infestation by animal pests, novel 1-(1 ,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compounds I and their agriculturally acceptable salts as well as to an agricultural composition comprising a 1-(1 ,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compound I or a salt thereof.
  [FR] The present invention relates to a method of combating animal pests which comprises contacting the animal pest, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal at- tack or infestation, with a pesticidally effective amount of at least one 1-(1 ,2-diphenyl- ethyl)-3-(2-hydroxyethyl)-thiourea compound I or an agriculturally acceptable salt thereof, wherein m is 0 to 5, n is 0 to 5, R³ and R⁴ are H or optionally substituted alkyl, haloalkyl, cycloalkyl, phenyl or benzyl, R⁷, R⁸, R⁹ and R¹⁰ are H or optionally substituted C₁-C₆-alkyl, C₁-C₆-haloalkyl, C₁-C₆- alkylamino, C₁-C₆-alkoxy, C₃-C₆-cycloalkyl, phenyl or benzyl and the variables R¹, R², R⁵ and R⁶ are as defined in the claims. The invention relates also to a method for protecting crops from attack or infestation by animal pests, a method for protecting non-living materials from attack or infestation by animal pests, novel 1-(1 ,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compounds I and their agriculturally acceptable salts as well as to an agricultural composition comprising a 1-(1 ,2-diphenyl-ethyl)-3-(2-hydroxyethyl)-thiourea compound I or a salt thereof.