(S)-1-benzyl-4-(pyrrolidin-2-yl)-1H-1,2,3-triazole | 1023279-49-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (S)-1-benzyl-4-(pyrrolidin-2-yl)-1H-1,2,3-triazole
• 英文别名: 1-benzyl-4-[(2S)-pyrrolidin-2-yl]triazole
• CAS: 1023279-49-3
• 化学式: C₁₃H₁₆N₄
• 分子量: 228.297
• InChiKey: ULONRRCAVRCVSE-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S)-tert-butyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)pyrrolidine-1-carboxylate 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以92%的产率得到(S)-1-benzyl-4-(pyrrolidin-2-yl)-1H-1,2,3-triazole
  参考文献：
  名称：

  Chiral pyrrolidine–triazole conjugate catalyst for asymmetric Michael and Aldol reactions

  摘要：

  A new pyrrolidine-triazole conjugate organocatalyst is synthesized using a Huisgen 1,3-dipolar cycloaddition reaction. The application of this catalyst in an asymmetric Michael addition and in an Aldol reaction is described, showing good catalytic activity. The reactions proceeded to give the products in good yield and in a highly selective manner. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.01.033

文献信息

• Chiral pyrrolidine–triazole conjugate catalyst for asymmetric Michael and Aldol reactions
  作者：S. Chandrasekhar、Bhoopendra Tiwari、Bibhuti B. Parida、Ch. Raji Reddy

  DOI：10.1016/j.tetasy.2008.01.033

  日期：2008.3

  A new pyrrolidine-triazole conjugate organocatalyst is synthesized using a Huisgen 1,3-dipolar cycloaddition reaction. The application of this catalyst in an asymmetric Michael addition and in an Aldol reaction is described, showing good catalytic activity. The reactions proceeded to give the products in good yield and in a highly selective manner. (C) 2008 Elsevier Ltd. All rights reserved.