6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline 2-oxide | 142597-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline 2-oxide
• 英文别名: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, 2-oxide；6,7-dimethoxy-2-methyl-2-oxido-3,4-dihydro-1H-isoquinolin-2-ium
• CAS: 142597-56-6
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: ZOOLWGISHSQSON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  36.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline 2-oxide 在 indium 、 氯化铵 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 以96%的产率得到2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Indium-mediated deoxygenation of amine-N-oxides in aqueous media

  摘要：

  Several aromatic and aliphatic amine-N-oxides were deoxygenated to the corresponding amines in good to quantitative yield using indium metal in neutral aqueous media. Other functional groups such as alkenes, halides, eaters, ethers, nitriles, amides and sulfones are unaffected under the present reaction conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00218-5

文献信息

• Indium-mediated deoxygenation of amine-N-oxides in aqueous media
  作者：J.S Yadav、B.V Subba Reddy、M.Muralidhar Reddy

  DOI：10.1016/s0040-4039(00)00218-5

  日期：2000.4

  Several aromatic and aliphatic amine-N-oxides were deoxygenated to the corresponding amines in good to quantitative yield using indium metal in neutral aqueous media. Other functional groups such as alkenes, halides, eaters, ethers, nitriles, amides and sulfones are unaffected under the present reaction conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.