(methoxymethyl)urea | 13824-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (methoxymethyl)urea
• 英文别名: Methoxymethyl-harnstoff；1-(Methoxymethyl)urea；methoxymethylurea
• CAS: 13824-21-0
• 化学式: C₃H₈N₂O₂
• 分子量: 104.109
• InChiKey: HJYNGRZUBXMFGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (methoxymethyl)urea 、 溶剂黄146 生成 聚合甲醛
  参考文献：
  名称：

  278.脲醛缩聚反应。第一部分甲氧基甲基脲水解的动力学

  摘要：

  DOI：

  10.1039/jr9570001446
• 作为产物：
  描述：

  甲醇 、 羟甲基脲 在 盐酸 作用下， 反应 0.17h， 生成 (methoxymethyl)urea
  参考文献：
  名称：

  The Formation Pathway of 3,5-Bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one

  摘要：

  对尿素及其甲基衍生物与甲醛的反应的研究阐明了3,5-双(甲氧基甲基)全氢-1,3,5-氧二嗪-4-酮的形成途径。1) 随着甲醛分子数量的增加，尿素与甲醛的加成反应变得越来越困难，这可能是由于羟甲基的立体位阻造成的。2) 3,5-双(甲氧基甲基)全氢-1,3,5-氧二嗪-4-酮被认为是通过三(羟甲基)脲和3-(羟甲基)全氢-1,3,5-氧二嗪-4-酮从尿素中衍生出来的，而不是通过四(羟甲基)脲或全氢-1,3,5-氧二嗪-4-酮。

  DOI：

  10.1246/bcsj.62.1930

文献信息

• Kadowaki, Bulletin of the Chemical Society of Japan, 1936, vol. 11, p. 253,256
  作者：Kadowaki

  DOI：——

  日期：——
• Monoethers of dimethylol urea and process for making same
  申请人：DU PONT

  公开号：US02247419A1

  公开（公告）日：1941-07-01
• Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland
  作者：R. Deghenghi、M. Papotti、E. Ghigo、G. Muccioli

  DOI：10.1007/bf03343800

  日期：2001.1

  Antagonism between GH secretagogues (GHS) and somatostatin (SRIH) has been postulated and demonstrated, but SRIH does not bind to GHS receptors (GHS-R) and potent synthetic peptidyl GHS (GHRP6, hexarelin) do not displace radiolabeled SRIH from its receptors, However, non-natural SRIH octapeptide agonists (mainly lanreotide and vapreotide) displace I-125-Tyr-Ala-hexarelin from pituitary binding sites suggesting that an endogenous factor related to SRIH might exist and interact with GHS-R, Our aims were to investigate the ability of different SRIH-like peptides such as various SRIH fragments (SRIH 3-14, SRIH 7-14, SRIH 3-10, SRIH 7-10, SRIH 2-9) and a natural neuropeptide that shows a high structural homology with SRIH such as cortistatin-14 (CST) to compete with I-125-Tyr-Ala-hexarelin for human pituitary binding sites and to compare their binding affinity with that of hexarelin and ghrelin, a gastric-derived peptidyl GHS that has been proposed as a natural ligand of GHS-R, While the binding of I-125-Tyr-Ala-hexarelin to pituitary membranes was completely displaced by unlabelled hexarelin, ghrelin and CST, none of the SRIH fragments tested inhibited this binding, Ghrelin and CST exhibited a similar affinity (4.6-5.4 x 10(-7) mol/l) for the binding while hexarelin was more effective by about four orders of magnitude in displacing I-125-Tyr-Ala-hexarelin. Our data demonstrate for the first time that cortistatin, a natural peptide related to SRIH, binds to GHS-R and suggest that this factor may play a role in modulating the activity of these receptors. (C) 2001, Editrice Kurtis.
• The Formation Pathway of 3,5-Bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one
  作者：Ryuichi Shiba、Miyuki Takahashi、Toichi Ebisuno、Michiaki Takimoto

  DOI：10.1246/bcsj.62.1930

  日期：1989.6

  The investigation of the reactions of urea and its methyl derivatives with formaldehyde elucidated the formation pathway of 3,5-bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one. 1) The addition of formaldehyde to urea became increasingly difficult according to the increase of the number of added formaldehyde molecules, probably because of the steric hindrance of the hydroxymethyl groups. 2) 3,5-Bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one was concluded to be derived from urea via tris(hydroxymethyl)urea and 3-(hydroxymethyl)perhydro-1,3,5-oxadiazin-4-one but not via tetrakis(hydroxymethyl)urea or perhydro-1,3,5-oxadiazin-4-one.

  对尿素及其甲基衍生物与甲醛的反应的研究阐明了3,5-双(甲氧基甲基)全氢-1,3,5-氧二嗪-4-酮的形成途径。1) 随着甲醛分子数量的增加，尿素与甲醛的加成反应变得越来越困难，这可能是由于羟甲基的立体位阻造成的。2) 3,5-双(甲氧基甲基)全氢-1,3,5-氧二嗪-4-酮被认为是通过三(羟甲基)脲和3-(羟甲基)全氢-1,3,5-氧二嗪-4-酮从尿素中衍生出来的，而不是通过四(羟甲基)脲或全氢-1,3,5-氧二嗪-4-酮。
• 278. The urea–formaldehyde polycondensation. Part I. Kinetics of the hydrolysis of methoxymethylurea
  作者：A. S. Dunn

  DOI：10.1039/jr9570001446

  日期：——