C-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-methylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: C-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-methylamine
• 英文别名: C-(4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isochinolin-5-yl)-methylamin；1-(4-Methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)methanamine；(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)methanamine
• 化学式: C₁₃H₁₈N₂O₃
• mdl: MFCD03006464
• 分子量: 250.298
• InChiKey: ODLCWRPXBNVZCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  57
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  C-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-methylamine 、 碘甲烷 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Dey; Kantam, Journal of the Indian Chemical Society, 1937, vol. 14, p. 91,92

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methoxy-6-methyl-5-nitromethyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 在 盐酸 、 tin(ll) chloride 作用下， 生成 C-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-methylamine
  参考文献：
  名称：

  Magidson; Gorbowizki, Chemische Berichte, 1935, vol. 68, p. 656,658

  摘要：

  DOI：

文献信息

• ANTAGONISM OF ABCG4, LYN KINASE, AND C-CBL E3 LIGASE TO INCREASE PLATELET COUNT AS THERAPY FOR THROMBOCYTOPENIA
  申请人：WANG Nan

  公开号：US20160067301A1

  公开（公告）日：2016-03-10

  The present invention provides a method of treating a subject to increase the subject's platelet count which comprises administering to the subject an amount of one or more of an antagonist or inhibitor of ABCG4, Lyn kinase or c-CBL effective to antagonize or inhibit such ABCG4, Lyn kinase or c-CBL so as to thereby increase the subject's platelet count.
• Magidson; Gorbowizki, Chemische Berichte, 1935, vol. 68, p. 656,658
  作者：Magidson、Gorbowizki

  DOI：——

  日期：——
• Dey; Kantam, Journal of the Indian Chemical Society, 1937, vol. 14, p. 91,92
  作者：Dey、Kantam

  DOI：——

  日期：——