1-[4-(4-Morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-2-ylamino)-phenyl]-cyclobutanecarboxylic acid methyl ester | 1215018-03-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[4-(4-Morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-2-ylamino)-phenyl]-cyclobutanecarboxylic acid methyl ester
• 英文别名: methyl 1-[4-[(4-morpholin-4-yl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)amino]phenyl]cyclobutane-1-carboxylate
• CAS: 1215018-03-3
• 化学式: C₂₃H₂₈N₄O₃
• 分子量: 408.5
• InChiKey: PNIKPQGMXUAVKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl 1-(4-aminophenyl)cyclobutane-1-carboxylate 、 2-chloro-4-morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidine 在 crude residue 、 silica gel 作用下， 以 异丙醇 为溶剂， 反应 18.0h， 以to afford the title compound as a white solid (0.24 g, 27% yield)的产率得到1-[4-(4-Morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-2-ylamino)-phenyl]-cyclobutanecarboxylic acid methyl ester
  参考文献：
  名称：

  Novel Biccyclic Compounds As GATA Modulators

  摘要：

  提供了新型双环化合物、立体异构体和/或该新型双环化合物的药物可接受盐，以及/或该新型双环化合物立体异构体的药物可接受盐。此外，还提供了制备新型双环化合物、立体异构体和/或该新型双环化合物的药物可接受盐，以及/或该新型双环化合物立体异构体的药物可接受盐的方法。

  公开号：

  US20100144731A1

文献信息

• Novel Biccyclic Compounds As GATA Modulators
  申请人：De Dibyendu

  公开号：US20100144731A1

  公开（公告）日：2010-06-10

  Novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of forming novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided.

  提供了新型双环化合物、立体异构体和/或新型双环化合物的药用可接受盐，以及新型双环化合物的立体异构体的药用可接受盐。此外，还提供了形成新型双环化合物、立体异构体和/或新型双环化合物的药用可接受盐，以及新型双环化合物的立体异构体的药用可接受盐的方法。
• US7989463B2
  申请人：——

  公开号：US7989463B2

  公开（公告）日：2011-08-02
• [EN] NOVEL BICCYCLIC COMPOUNDS AS GATA MODULATORS<br/>[FR] NOUVEAUX COMPOSÉS BICYCLIQUES COMME MODULATEURS DE GATA
  申请人：REDDYS LAB LTD DR

  公开号：WO2010028174A1

  公开（公告）日：2010-03-11

  Novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of forming novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided.
• Biccyclic compounds as GATA modulators
  申请人：Dr. Reddy's Laboratories Limited

  公开号：US07989463B2

  公开（公告）日：2011-08-02

  Novel bicyclic compounds of the formula (I), stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of forming novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided: wherein R1, R2, m, and n are defined herein.

  本发明提供了式(I)的新型双环化合物、立体异构体和/或其药学上可接受的盐，以及新型双环化合物立体异构体和/或其药学上可接受的盐的药学上可接受的盐。此外，本发明还提供了制备新型双环化合物、立体异构体和/或其药学上可接受的盐，以及新型双环化合物立体异构体和/或其药学上可接受的盐的方法。其中，R1、R2、m和n如本文所定义。