(1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,21-dihydroxy-9-methoxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one | 1093243-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,21-dihydroxy-9-methoxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one
• CAS: 1093243-42-5
• 化学式: C₃₀H₄₄O₆
• 分子量: 500.676
• InChiKey: KJJYUDJHZQVBJL-NRZNTJPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,21-dihydroxy-9-methoxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one 在 水 作用下， 以 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl

  摘要：

  The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.071

文献信息

• Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl
  作者：Christian O. Janssen、Stephanie Lim、Ee Peng Lo、Kah Fei Wan、Victor C. Yu、May Ann Lee、Siew Bee Ng、Martin J. Everett、Antony D. Buss、David P. Lane、Rustum S. Boyce

  DOI：10.1016/j.bmcl.2008.09.071

  日期：2008.11

  The cytotoxic macrolide kendomycin was identified as a ligand of Bcl-xl, an anti-apoptotic member of the Bcl-2 protein family. Hydrolysis-stable and protonable semi-synthetic analogues have been obtained that retain cytotoxicity and Bcl-xl binding. (C) 2008 Elsevier Ltd. All rights reserved.