osyrisine | 1309362-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯里西啶类
• 英文名称: osyrisine
• 英文别名: [(1R,8S)-2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-yl]methyl 2-methylbutanoate
• CAS: 1309362-91-1
• 化学式: C₁₃H₂₃NO₂
• 分子量: 225.331
• InChiKey: GZYSVGWNLDGWPZ-RAMGSTBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  osyrisine 在 甲醇 、 sodium hydroxide 作用下， 反应 3.0h， 以2 mg的产率得到颈花脒
  参考文献：
  名称：

  Chemical constituents ofOsyris albaand their antiparasitic activities

  摘要：

  Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis. Osyrisine, catechin, and catechin-3-O--l-rhamnopyranoside exhibited a significant level of antiparasitic activity against two parasites, Entamoeba histolytica and Giardia intestinalis.

  DOI：

  10.1080/10286020.2010.502892

文献信息

• Chemical constituents of<i>Osyris alba</i>and their antiparasitic activities
  作者：Hala I. Al-Jaber、Ibrahim M. Mosleh、Abdallah Mallouh、Omar M. Abu Salim、Musa H. Abu Zarga

  DOI：10.1080/10286020.2010.502892

  日期：2010.9

  Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis. Osyrisine, catechin, and catechin-3-O--l-rhamnopyranoside exhibited a significant level of antiparasitic activity against two parasites, Entamoeba histolytica and Giardia intestinalis.