6-methyl-3-(1H-imidazo[4,5-f][1,10]phenanthroline-2-yl)-4H-chromene-4-one | 910137-40-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 6-methyl-3-(1H-imidazo[4,5-f][1,10]phenanthroline-2-yl)-4H-chromene-4-one
• 英文别名: 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline；MCMIP；3-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-6-methylchromen-4-one
• CAS: 910137-40-5
• 化学式: C₂₃H₁₄N₄O₂
• 分子量: 378.39
• InChiKey: IIAPZBPVGIIUCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 、 sodium perchlorate 、 6-methyl-3-(1H-imidazo[4,5-f][1,10]phenanthroline-2-yl)-4H-chromene-4-one 以 乙醇 、 水 为溶剂， 以68.48%的产率得到[Ru(phen)2(mipc)](ClO4)2*2H2O
  参考文献：
  名称：

  Ru(II) 多吡啶配合物的合成、DNA 结合、细胞毒性、光裂解、抗菌和对接研究

  摘要：

  三种钌 (II) 多吡啶配合物，[Ru(phen) 2 (mipc)] 2+ (1)、[Ru(bpy) 2 (mipc)] 2+ (2) 和 [Ru (dmb) 2 (mipc)] 2+ (3) [mipc = 2-(6-methyl-3-(1H-imidazo[4, 5-f][1,10]-phenanthroline-2-yl)-4H-chromene-4-one, phen = 1,10-菲咯啉,bpy = 2, 2'bipyridine,dmb = 4, 4'-二甲基-2, 2'-bipyridine] 已合成并通过元素分析、IR、UV-Vis、1 H& 13表征C NMR和质谱。通过分光光度法、粘度测量和光开关研究研究了钌 (II) 复合物的 DNA 结合特性。这三种复合物一直专注于 pBR-322 的光活化裂解研究和抗菌研究。实验结果表明，这三种复合物嵌入到DNA碱基对中并分别遵循1

  DOI：

  10.1007/s10895-013-1209-7

文献信息

• Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline: Synthesis, DNA-binding and photocleavage studies
  作者：Yun-Jun Liu、Hui Chao、Yi-Xian Yuan、Hui-Juan Yu、Liang-Nian Ji

  DOI：10.1016/j.ica.2006.05.015

  日期：2006.9

  Two novel Ru(II) complexes [Ru(bpy),(MCMIP)](2+) (1) and [Ru(phen)(2)(MCMIP)](2+) (2) (bpy = 2,2'-bipyridine; phen = 1, 10-phenanthroline; MCMIP = 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline) have been synthesized and characterized by elemental analysis, mass spectra and H-1 NMR. The DNA-binding properties of the complexes were investigated by absorption, emission, melting temperature and viscosity measurements. Experimental results indicate that the two complexes can intercalate into DNA base pairs. Upon irradiation at 365 nm, two Ru(11) complexes were found to promote the cleavage of plasmid pBR 322 DNA from super-coiled form I to nicked form II, and the mechanisms for DNA cleavage by the complexes were also investigated. (c) 2006 Elsevier B.V. All rights reserved.