5-(二甲基氨基)-N-十八烷基-1-萘磺酰胺 | 63839-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 5-(二甲基氨基)-N-十八烷基-1-萘磺酰胺
• 英文名称: 5-(dimethylamino)-N-octadecylnaphthalene-1-sulfonamide
• CAS: 63839-19-0
• 化学式: C₃₀H₅₀N₂O₂S
• 分子量: 502.805
• InChiKey: GIYVPMYXSYDETD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.2
• 重原子数：
  35
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丹酰氯 、 十八胺 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以74.5%的产率得到5-(二甲基氨基)-N-十八烷基-1-萘磺酰胺
  参考文献：
  名称：

  Drug-Loaded Fluorescent Cubosomes: Versatile Nanoparticles for Potential Theranostic Applications

  摘要：

  In this work, monoolein-based cubosomes were doped with two fluorescent probes, namely, fluoresce in and dansyl, properly modified with a hydrocarbon chain to increase their encapsulation efficiency within the monoolein palisade. The same nanocarriers were also loaded, with quercetin, a hydrophobic molecule with potential anticancer activity. Particularly, the cubosomes doped with the modified fluorescein probe were successfully exploited for single living cell, imaging. The physicochemical and photophysical characterizations reported here, along with the well-known ability of cubosomes in hosting molecules with pharmaceutical interest, strongly encourage the use of these innovative fluorescent nanocarriers for theranostic purposes.

  DOI：

  10.1021/la401047a