5-(naphthalen-1-ylmethyl)-N-phenyl-1,3-thiazol-2-amine | 300827-55-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(naphthalen-1-ylmethyl)-N-phenyl-1,3-thiazol-2-amine
• CAS: 300827-55-8
• 化学式: C₂₀H₁₆N₂S
• 分子量: 316.426
• InChiKey: XAOYELZDXKFSRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-naphthalenediazonium tetrachlorocuprate(II) 以 乙醇 为溶剂， 反应 3.0h， 生成 5-(naphthalen-1-ylmethyl)-N-phenyl-1,3-thiazol-2-amine
  参考文献：
  名称：

  Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds 22.* 3-Aryl-2-chloropropanal in the synthesis of N-Aryl-5-(R-benzyl)-1,3-thiazole-2-amines

  摘要：

  3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl-and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.

  DOI：

  10.1007/s10593-010-0537-7

文献信息

• Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds 22.* 3-Aryl-2-chloropropanal in the synthesis of N-Aryl-5-(R-benzyl)-1,3-thiazole-2-amines
  作者：V. S. Matiychuk、N. D.Obushak、N. I. Pidlypnyi、Yu. V. Ostapiuk、R. M. Voloshchuk

  DOI：10.1007/s10593-010-0537-7

  日期：2010.8

  3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl-and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.