phenazine-1-acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: phenazine-1-acetic acid
• 英文别名: 1-carboxymethyl phenazine；2-phenazin-1-ylacetic acid
• 化学式: C₁₄H₁₀N₂O₂
• 分子量: 238.246
• InChiKey: NAFPKPVWDZARKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  phenazine-1-acetonitrile 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 以55%的产率得到phenazine-1-acetic acid
  参考文献：
  名称：

  潜在的抗肿瘤药。62.与结肠肿瘤活性药物9-氧代-9H-氧杂蒽-4-乙酸有关的三环化合物的构效关系。

  摘要：

  已经制备了一系列9-氧代-9H-氧杂蒽-4-乙酸的三环类似物，并评估了它们在小鼠皮下植入的结肠38肿瘤中引起出血性坏死的能力，以期扩展其结构-活性关系。这个系列。如先前在黄酮8-乙酸（FAA）的类似物中所发现的（Atwell等人，Anti-Cancer Drug Des。1989，4，161），XAA核的所有电子修饰均导致活性的严重降低或完全取消。 ，表明结构-活性关系狭窄。计算了许多化合物的偶极矩，发现分子偶极矩离开这些分子芳族部分平面的程度很大程度上取决于乙酸部分相对于乙酸部分的贡献。三环系统。偶极矩的大小与活动之间似乎没有任何一般的关系。但是，对于含有9-羰基官能团的化合物，偶极向量的方向可能很重要。在所有具有位于乙酸侧链周围的醚基的化合物中，该化合物与侧链OH之间存在接近的途径（约2.4 A）。

  DOI：

  10.1021/jm00106a003

文献信息

• BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY
  申请人：Wilsey Christopher D.

  公开号：US20090246808A1

  公开（公告）日：2009-10-01

  A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

  用于测定生物体液中分析物浓度的化学基质包括葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺。该化学基质与电化学生物传感器一起使用，以测定反应发生后分析器检测到的分析物浓度。使用葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺的化学基质测定分析物浓度的方法是另一个方面的描述。该方法还特别具有五秒或更短的测试时间。利用新的化学基质的方法可以方便地测定分析物，例如血糖，在pH值约为6.5至约8.5的浓度范围内，浓度为约20-600 mg/dL。
• METHODS FOR ELECTROCHEMICAL ANALYSIS USING MATRIX COMPOSITIONS WITH ALKYLPHENAZINE QUATERNARY SALT AND A NITROSALINE
  申请人：Wilsey Christopher D.

  公开号：US20110290670A1

  公开（公告）日：2011-12-01

  A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

  一种用于确定生物体液中分析物浓度的化学基质，包括葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺。该化学基质与电化学生物传感器一起使用，以确定反应发生后分析仪中的分析物浓度，然后完成分析以确定浓度。另外还描述了使用葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺的化学基质来确定分析物浓度的方法。该方法还具有5秒或更短的测试时间。利用新的化学基质的方法可以轻松地确定分析物，例如血糖，在pH值为6.5至8.5之间的浓度范围内，浓度为20-600毫克/分升。
• Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US08008037B2

  公开（公告）日：2011-08-30

  A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

  用于确定生物流体中分析物浓度的化学矩阵包括葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺。化学矩阵与电化学生物传感器一起使用，以确定反应在生物传感器内后的分析物浓度，此时进行分析以确定浓度。还描述了使用葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺的化学矩阵来确定分析物浓度的方法。该方法还具有5秒或更短的测试时间。利用新的化学矩阵的方法可以轻松地确定分析物，如血糖，浓度为约20-600 mg/dL，在pH值约为6.5至约8.5。
• Methods for electrochemical analysis using matrix compositions with alkylphenazine quaternary salt and a nitrosoaniline
  申请人：Wilsey Christopher D.

  公开号：US08535511B2

  公开（公告）日：2013-09-17

  A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

  一种用于测定生物流体中分析物浓度的化学基质，包括葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺。该化学基质与电化学生物传感器一起使用，以确定在生物传感器内发生反应后分析完成时的分析物浓度。描述了使用葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺的化学基质测定分析物浓度的方法。该方法还具有5秒或更短的测试时间。利用新的化学基质的方法可以轻松地确定分析物，例如血糖，在pH为6.5至8.5左右的浓度范围内，浓度为约20-600毫克/分升。
• REWCASTLE, GORDON W.;ATWELL, GRAHAM J.;PALMER, BRIAN D.;BOYD, PETER D. W.+, J. MED. CHEM., 34,(1991) N, C. 491-496
  作者：REWCASTLE, GORDON W.、ATWELL, GRAHAM J.、PALMER, BRIAN D.、BOYD, PETER D. W.+

  DOI：——

  日期：——