5-Hydroxy-2,3-di-p-tolylmercapto-naphthochinon-(1,4) | 116975-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-Hydroxy-2,3-di-p-tolylmercapto-naphthochinon-(1,4)
• 英文别名: 5-Hydroxy-2,3-bis(p-tolylsulfanyl)naphthalene-1,4-dione；5-hydroxy-2,3-bis[(4-methylphenyl)sulfanyl]naphthalene-1,4-dione
• CAS: 116975-27-0
• 化学式: C₂₄H₁₈O₃S₂
• 分子量: 418.537
• InChiKey: BXXXJMRGRMRGJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-dichloro-5-hydroxy-1,4-naphthoquinone 、 4-甲苯硫酚 以 乙醇 为溶剂， 反应 5.0h， 以54%的产率得到5-Hydroxy-2,3-di-p-tolylmercapto-naphthochinon-(1,4)
  参考文献：
  名称：

  Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones

  摘要：

  2/3-Arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones 5-9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5-9 generally showed good activities against Candida albicans and C tropicalis. The results suggest that the 1,4-naphthoquinones 5-9 would be potent antifungal agents. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.12.004

文献信息

• Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones
  作者：Chung-Kyu Ryu、Ju-Yeon Shim、Mi Jin Chae、Ik Hwa Choi、Ja-Young Han、Ok-Jai Jung、Jung Yoon Lee、Seong Hee Jeong

  DOI：10.1016/j.ejmech.2004.12.004

  日期：2005.5

  2/3-Arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones 5-9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5-9 generally showed good activities against Candida albicans and C tropicalis. The results suggest that the 1,4-naphthoquinones 5-9 would be potent antifungal agents. (c) 2005 Elsevier SAS. All rights reserved.