叔丁基甲基亚砜 | 10269-14-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 中文名称: 叔丁基甲基亚砜
• 英文名称: Bis-neopentyl-sulfoxid
• 英文别名: Dineopentyl-sulfoxid；tert-butylmethyl sulfoxide；dineopentyl sulfoxide；bis-(2,2-dimethyl-propyl) sulfoxide；1-(2,2-Dimethylpropylsulfinyl)-2,2-dimethylpropane
• CAS: 10269-14-4
• 化学式: C₁₀H₂₂OS
• 分子量: 190.35
• InChiKey: BUJAQQOCIQWCOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  叔丁基甲基亚砜 在 过氧化氢苯甲酰 作用下， 生成 Dineopentyl-sulphon
  参考文献：
  名称：

  氧化有机硫化物十五：对亚砜碱氧化成砜的立体效应

  摘要：

  高度支化的戊基亚烷基和二烷基亚砜的氧化表明，在碱性氧化中，即使位阻作用不是很大，位阻也比在酸性氧化中具有更显着的影响。基于这些和先前的结果，提出了关于碱性氧化的过渡态的几何构型的一些建议。

  DOI：

  10.1016/s0040-4020(01)99414-1
• 作为产物：
  描述：

  2,2-dimethyl-propane-1-sulfinic acid methyl ester 、 neopentylmagnesium bromide 以 乙醚 为溶剂， 生成 叔丁基甲基亚砜
  参考文献：
  名称：

  氧化有机硫化物十五：对亚砜碱氧化成砜的立体效应

  摘要：

  高度支化的戊基亚烷基和二烷基亚砜的氧化表明，在碱性氧化中，即使位阻作用不是很大，位阻也比在酸性氧化中具有更显着的影响。基于这些和先前的结果，提出了关于碱性氧化的过渡态的几何构型的一些建议。

  DOI：

  10.1016/s0040-4020(01)99414-1

文献信息

• COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
  申请人：Auclair Karine

  公开号：US20140038914A1

  公开（公告）日：2014-02-06

  This invention relates to a compound of Formula 1A: or a pharmaceutically acceptable salt thereof; wherein R1 to R4, R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharmaceutically acceptable salt thereof; and method of using same for reducing or reversing bacterial resistance to at least one aminoglycoside antibiotic.
• METHOD OF TREATING IRON DEFICIENCY
  申请人：Industrial Technology Research Institute

  公开号：US20160008292A1

  公开（公告）日：2016-01-14

  A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.
• METHOD FOR IMMUNE CELL TRACKING
  申请人：Industrial Technology Research Institute

  公开号：US20160008491A1

  公开（公告）日：2016-01-14

  A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.
• DISULFIDE COMPOUNDS FOR DELIVERY OF PHARMACEUTICAL AGENTS
  申请人：XU Qiaobing

  公开号：US20160009643A1

  公开（公告）日：2016-01-14

  A compound of formula the following formula: (I). In this formula, moieties A, B, X, R 1 , R 2 , and R 3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a pharmaceutical agent, and a nanocomplex that is formed of a protein and a bioreducible compound.
• NANOCOMPLEXES FOR DELIVERY OF SAPORIN
  申请人：TUFTS UNIVERSITY

  公开号：US20160082126A1

  公开（公告）日：2016-03-24

  A nanocomplex, of particle size 50 nm to 1000 nm, containing saporin and a lipid-like compound, in which saporin binds to the lipid-like compound via non-covalent interaction or covalent bonding. The lipid-like compound has a hydrophilic moiety, a hydrophobic moiety, and a linker joining the hydrophilic moiety and the hydrophobic moiety. The hydrophilic moiety is optionally charged and the hydrophobic moiety has 8 to 24 carbon atoms. Also disclosed is a pharmaceutical composition containing such a nanocomplex and a pharmaceutically acceptable carrier. The nanocomplex is useful in treating diseases, such as cancer.