1,1-dimethylethyl 2-(methylamino)-2-oxoethyl piperazine-1,4-dicarboxylate | 855787-56-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,1-dimethylethyl 2-(methylamino)-2-oxoethyl piperazine-1,4-dicarboxylate
• 英文别名: 1,1-dimethylethyl 2-(methylamino)-2-oxoethyl 1,4-piperazinedicarboxylate；4-O-tert-butyl 1-O-[2-(methylamino)-2-oxoethyl] piperazine-1,4-dicarboxylate
• CAS: 855787-56-3
• 化学式: C₁₃H₂₃N₃O₅
• 分子量: 301.343
• InChiKey: IRAFINHHASGAMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,1-dimethylethyl 2-(methylamino)-2-oxoethyl piperazine-1,4-dicarboxylate 在 盐酸 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 1.0h， 生成 2-(methylamino)-2-oxoethyl piperazine-1-carboxylate hydrochloride
  参考文献：
  名称：

  DERIVATIVES OF ALKYLPIPERAZINE AND ALKYLHOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS

  摘要：

  本发明涉及烷基哌嗪和烷基同源哌嗪羧酸盐及其衍生物，其制备方法以及作为脂肪酸酰胺水解酶（FAAH）酶抑制剂的治疗用途。这些衍生物通过与大麻素和辣椒素受体等相互作用，发挥各种药理活性。通过抑制FAAH酶的代谢活性，通常导致疾病发作和其他病理状况的化合物不会生成，疾病的发生率大大降低。

  公开号：

  US20070027141A1
• 作为产物：
  描述：

  4-nitrophenyl 2-(methylamino)-2-oxoethyl carbonate 、 N-Boc-哌嗪 以 1,2-二氯乙烷 为溶剂， 反应 4.0h， 生成 1,1-dimethylethyl 2-(methylamino)-2-oxoethyl piperazine-1,4-dicarboxylate
  参考文献：
  名称：

  Derivatives of alkylpiperazine- and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors

  摘要：

  本发明包括烷基哌嗪和烷基同型哌嗪羧酸盐及其衍生物，其制备方法以及作为脂肪酸酰胺水解酶（FAAH）酶抑制剂的治疗用途。这些衍生物通过与大麻素和辣椒素受体等相互作用，发挥各种药理活性。通过抑制FAAH酶的代谢活性，通常导致疾病和其他病理状况的化合物不会生成，疾病的发生率大大降低。

  公开号：

  US07973042B2

文献信息

• Derivatives of 1-piperazine-and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme
  申请人：Abouabdellah Ahmed

  公开号：US20060293310A1

  公开（公告）日：2006-12-28

  The invention relates to a compound having general formula (I): Wherein m, R 1 and R 2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

  这项发明涉及具有一般式(I)的化合物：其中m，R1和R2如本文所定义。该发明还涉及该化合物在治疗中的应用。更具体地说，该发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。
• DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME
  申请人：ABOUABDELLAH Ahmed

  公开号：US20100137329A1

  公开（公告）日：2010-06-03

  The invention relates to a compound having general formula (I): Wherein m, R 1 and R 2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

  本发明涉及具有一般式（I）的化合物：其中m、R1和R2如本文所定义。本发明还涉及化合物在治疗学中的应用。更具体地说，本发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。
• Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme
  申请人：Sanofi-Aventis

  公开号：US08114866B2

  公开（公告）日：2012-02-14

  The invention relates to a compound having general formula (I): Wherein m, R1 and R2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

  本发明涉及具有一般式（I）的化合物：其中m，R1和R2如本文所定义。本发明还涉及该化合物在治疗中的应用。更具体地说，本发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。
• DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS
  申请人：Abouabdellah Ahmed

  公开号：US20090143365A1

  公开（公告）日：2009-06-04

  The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.

  本发明涉及烷基哌嗪和烷基同型哌嗪羧酸盐及其衍生物，其制备方法以及作为脂肪酸酰胺水解酶（FAAH）酶抑制剂的治疗用途。这些衍生物通过与大麻素和辣椒素受体等相互作用，发挥各种药理活性。通过抑制FAAH酶的代谢活性，通常会导致疾病和其他病理状况的化合物不会生成，从而大大降低了疾病的发生率。
• US7482346B2
  申请人：——

  公开号：US7482346B2

  公开（公告）日：2009-01-27