The first diastereoselective chiral synthesis of (+)-viroallosecurinine, isolated front Securinega virosa as a cytotoxic alkaloid, was achieved by using a chelation-controlled addition of an alkyne moiety to the corresponding ketone, and a ring-metathesis, as key reactions. (C) 2004 Elsevier Ltd. All rights reserved.
The first diastereoselective chiral synthesis of (+)-viroallosecurinine, isolated front Securinega virosa as a cytotoxic alkaloid, was achieved by using a chelation-controlled addition of an alkyne moiety to the corresponding ketone, and a ring-metathesis, as key reactions. (C) 2004 Elsevier Ltd. All rights reserved.
The first diastereoselective chiral synthesis of (+)-viroallosecurinine, isolated front Securinega virosa as a cytotoxic alkaloid, was achieved by using a chelation-controlled addition of an alkyne moiety to the corresponding ketone, and a ring-metathesis, as key reactions. (C) 2004 Elsevier Ltd. All rights reserved.