7-甲基-2-萘-2-基-3-亚硝基咪唑并[1,2-a]吡啶 | 364043-77-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 7-甲基-2-萘-2-基-3-亚硝基咪唑并[1,2-a]吡啶
• 英文名称: Imidazo(1,2-a)pyridine, 7-methyl-2-(2-naphthalenyl)-3-nitroso-
• 英文别名: 7-methyl-2-naphthalen-2-yl-3-nitrosoimidazo[1,2-a]pyridine
• CAS: 364043-77-6
• 化学式: C₁₈H₁₃N₃O
• 分子量: 287.321
• InChiKey: WKFMQFSCDPRVJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-methyl-2-(naphth-2-yl)imidazo[1,2-a]pyridine 在 溶剂黄146 、 sodium nitrite 作用下， 反应 0.5h， 以78%的产率得到7-甲基-2-萘-2-基-3-亚硝基咪唑并[1,2-a]吡啶
  参考文献：
  名称：

  Synthesis of 3-Nitrosoimidazo[1,2-a]pyridine Derivatives as Potential Antiretroviral Agents

  摘要：

  Ten 2-aryl or heteroaryl-3-nitrosoimidazo[1,2-a]pyridine derivatives were synthesised as potential antiretroviral agents. The new compounds were characterized by elemental analysis, (1)H NMR, and by crystallography for (14). The compounds were devoid of any activity against HIV-1 or HIV-2.

  DOI：

  10.1002/1521-4184(200107)334:7<224::aid-ardp224>3.0.co;2-7

文献信息

• Synthesis of 3-Nitrosoimidazo[1,2-a]pyridine Derivatives as Potential Antiretroviral Agents
  作者：Aziz Chaouni-Benabdallah、Christophe Galtier、Hassan Allouchi、Abdelhak Kherbeche、Jean-Claude Debouzy、Jean-Claude Teulade、Olivier Chavignon、Myriam Witvrouw、Christophe Pannecouque、Jan Balzarini、Erik de Clercq、Cécile Enguehard、Alain Gueiffier

  DOI：10.1002/1521-4184(200107)334:7<224::aid-ardp224>3.0.co;2-7

  日期：2001.7

  Ten 2-aryl or heteroaryl-3-nitrosoimidazo[1,2-a]pyridine derivatives were synthesised as potential antiretroviral agents. The new compounds were characterized by elemental analysis, (1)H NMR, and by crystallography for (14). The compounds were devoid of any activity against HIV-1 or HIV-2.