4-(chloro-[1]naphthyl-methyl)-anisole | 725239-77-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(chloro-[1]naphthyl-methyl)-anisole
• 英文别名: 4-(Chlor-[1]naphthyl-methyl)-anisol；(+/-)-(4-Methoxy-phenyl)-(naphthyl-(1))-methylchlorid；(+/-)-4-Methoxy-1-[chlor-(naphthyl-(1))-methyl]-benzol；(+/-)-1-(α-Chlor-4-methoxy-benzyl)-naphthalin；1-[Chloro-(4-methoxyphenyl)methyl]naphthalene
• CAS: 725239-77-0
• 化学式: C₁₈H₁₅ClO
• 分子量: 282.769
• InChiKey: UTYOEFASDZWWIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(chloro-[1]naphthyl-methyl)-anisole 以 苯 为溶剂， 反应 12.0h， 生成 1-[methoxy(4-methoxypehnyl)methyl]naphthalene
  参考文献：
  名称：

  Alonso, E. O.; Johnston, L. J.; Scaiano, J. C., Canadian Journal of Chemistry, 1992, vol. 70, # 6, p. 1784 - 1794

  摘要：

  DOI：
• 作为产物：
  描述：

  (4-methoxyphenyl)(naphthalen-1-yl)methanol 在 盐酸 作用下， 生成 4-(chloro-[1]naphthyl-methyl)-anisole
  参考文献：
  名称：

  Balfe et al., Journal of the Chemical Society, 1946, p. 797,802

  摘要：

  DOI：

文献信息

• Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease
  申请人：——

  公开号：US20020119953A1

  公开（公告）日：2002-08-29

  The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

  本发明提供了一类化合物，可作为治疗镰状细胞病和以不需要的或异常的细胞增殖为特征的疾病，特别是与不需要的细胞增殖有关的炎症性疾病的有效药物。这些活性化合物是取代的三芳基甲烷化合物或其类似物，其中一个或多个芳基被杂芳基、环烷基或杂环烷基取代，和/或三级碳原子被不同的原子如 Si、Ge、N 或 P 取代。这些化合物可抑制哺乳动物细胞增殖，抑制红细胞的加多斯通道，减少镰状红细胞脱水和/或延缓红细胞镰状化或变形的发生。
• Method for reducing chloride secretion by intestinal epithelial cells in situ: use of triaryl methane compounds
  申请人：——

  公开号：US20030119784A1

  公开（公告）日：2003-06-26

  A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.

  本发明提供了一种治疗和预防腹泻和溃疡的方法和产品。该方法包括用本发明的芳香族化合物治疗腹泻、或溃疡、或有腹泻或溃疡风险的受试者。本发明的产品是本发明芳香族化合物和抗溃疡剂的兽用制剂，以及本发明芳香族化合物和抗腹泻剂的药用制剂。
• Balfe et al., Journal of the Chemical Society, 1946, p. 797,802
  作者：Balfe et al.

  DOI：——

  日期：——
• EP0918514A4
  申请人：——

  公开号：EP0918514A4

  公开（公告）日：2001-05-09
• TRIARYL METHANE COMPOUNDS FOR SICKLE CELL DISEASE
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：EP0918514A1

  公开（公告）日：1999-06-02