allyl 1-chloroethylcarbonate | 91507-59-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: allyl 1-chloroethylcarbonate
• 英文别名: 1-Chloroethyl prop-2-enyl carbonate
• CAS: 91507-59-4
• 化学式: C₆H₉ClO₃
• 分子量: 164.589
• InChiKey: ITKWWPHKXAQJKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  allyl 1-chloroethylcarbonate 在 四正丁基溴化膦 作用下， 以 丙酮 为溶剂， 反应 53.0h， 生成 allyl 1-isothiocyanoethylcarbonate
  参考文献：
  名称：

  硫辛酸和异硫氰酸酯取代的碳酸酯和氨基甲酸酯的合成

  摘要：

  烷基1-氯乙基碳酸酯1的反应和1-氯乙基N，N-二烷基氨基甲酸盐与MSCN（M = K，NH 4在丙酮或在质子溶剂（甲醇，HCONH）2），得到相应的硫代-和/或异硫氰基衍生物丰产。

  DOI：

  10.1016/s0040-4020(01)86723-5

文献信息

• [EN] COMPOSITION FOR LOWERING BLOOD-SUGAR LEVEL<br/>[FR] COMPOSITION POUR ABAISSER LA GLYCEMIE
  申请人：OSAKA IND PROMOTION ORG

  公开号：WO2005009471A1

  公开（公告）日：2005-02-03

  The present invention provides compositions, which have an action to lower blood sugar levels in subjects in a hyperglycemic state based on a mechanism that is different from conventional drugs to treat diabetes, and which are used for lowering the blood sugar levels of the subjects. The present invention also provides compositions to prevent or treat diseases caused by hyperglycemia, specifically, diabetes and the complications of diabetes, based on the action above. The invention further provides a method to lower blood sugar levels of subjects in a hyperglycemic state, and a method to prevent or threat diseases caused by hyperglycemia, using a hypoglycemic action based on the novel mechanism of action of the composition. The present invention also provides a method to screen the active ingredient of the above compositions. The present invention provides novel imidazole compounds represented by formula (1), which has an action of lowering the blood sugar level of a subject in a hyperglycemic state, and is useful as an active ingredient of a hypoglycemic composition, or an active ingredient of a composition that can be used for preventing or treating disorders caused by hyperglycemia, specifically diabetes and complications of diabetes.

  本发明提供了一种组合物，具有降低高血糖状态下受试者血糖水平的作用，其机制与传统治疗糖尿病的药物不同，并且用于降低受试者的血糖水平。本发明还提供了一种组合物，用于预防或治疗由高血糖引起的疾病，特别是糖尿病及糖尿病并发症，其基于上述作用。该发明还提供了一种降低高血糖状态下受试者血糖水平的方法，以及一种预防或治疗由高血糖引起的疾病的方法，使用基于组合物新机制的降血糖作用。本发明还提供了一种筛选上述组合物活性成分的方法。本发明提供了一种由式（1）表示的新型咪唑化合物，具有降低高血糖状态下受试者血糖水平的作用，并可作为降血糖组合物的活性成分，或用于预防或治疗由高血糖引起的疾病，特别是糖尿病及糖尿病并发症的组合物的活性成分。
• Synthesis, acaricidal activities and docking study of novel acrylonitrile derivatives
  作者：Liang-Kun Zhong、Sheng-Jie Kang、Cheng-Xia Tan、Jian-Quan Weng、Tian-Ming Xu、Xing-Hai Liu

  DOI：10.24820/ark.5550190.p011.074

  日期：——

  A series of novel acrylonitrile derivatives containing a flexible chain were designed using cyflumetofen as lead compound. They were synthesized via two steps. The structures were confirmed by 1H NMR, 13C NMR and HRMS. The title acrylonitrile derivatives exhibited good acaricidal activity against Tetranchus urticae. In particular, 3j possessed excellent activity in the green house, at the same level

  以氟虫腈为先导化合物，设计了一系列含有柔性链的新型丙烯腈衍生物。它们通过两个步骤合成。结构经1H NMR、13C NMR和HRMS证实。标题丙烯腈衍生物对荨麻疹表现出良好的杀螨活性。尤其是，3j 在温室中具有极好的活性，在 4 天或 7 天时与对照氟美托芬处于同一水平。
• Prodrugs of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their use in transdermal therapeutic systems
  申请人：Hexal AG

  公开号：EP2537534A1

  公开（公告）日：2012-12-26

  The present invention relates to diester prodrugs of cilazaprilate which undergo enzymatic cleavage to release the active metabolite cilazaprilate that is used for the treatment of hypertension and congestive heart failure. Furthermore the diester prodrugs of cilazaprilate possess all the properties necessary to be topically administered, preferably via transdermal therapeutic systems.

  本发明涉及西拉普利酸二酯原药，该原药经过酶裂解后释放出活性代谢物西拉普利酸，用于治疗高血压和充血性心力衰竭。此外，西拉普利酸二酯原药具有局部给药所需的所有特性，最好是通过透皮治疗系统给药。
• Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.
  申请人：Hexal AG

  公开号：EP2537534B1

  公开（公告）日：2014-12-17
• RIONDEL, A.;CAUBERE, P.;SENET, J. P.;LECOLIER, S., TETRAHEDRON, 44,(1988) N 6, 1619-1630
  作者：RIONDEL, A.、CAUBERE, P.、SENET, J. P.、LECOLIER, S.

  DOI：——

  日期：——