1-tert-butyl 3-methyl (3R,4S)-4-(2,4,5-trifluorophenyl)piperidine-1,3-dicarboxylate | 882856-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-tert-butyl 3-methyl (3R,4S)-4-(2,4,5-trifluorophenyl)piperidine-1,3-dicarboxylate
• 英文别名: 1-tert-Butyl 3-methyl (3R,4S)-4-(2,4,5-trifluorophenyl)piperidine-1,3-dicarboxylate；1-O-tert-butyl 3-O-methyl (3R,4S)-4-(2,4,5-trifluorophenyl)piperidine-1,3-dicarboxylate
• CAS: 882856-70-4
• 化学式: C₁₈H₂₂F₃NO₄
• 分子量: 373.372
• InChiKey: RJFBCAMQXGFVJW-PWSUYJOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-tert-butyl 3-methyl (3R,4S)-4-(2,4,5-trifluorophenyl)piperidine-1,3-dicarboxylate 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 16.0h， 生成 (3R,4S)-1-(tert-butoxycarbonyl)-4-(2,4,5-trifluorophenyl)piperidme-3-carboxylic acid
  参考文献：
  名称：

  [EN] AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  [FR] AMINOPIPERIDINES UTILISEES COMME INHIBITEURS DE LA DIPEPTIDYLE PEPTIDASE-IV POUR LE TRAITEMENT OU LA PREVENTION DU DIABETE

  摘要：

  公开号：

  WO2006039325A3
• 作为产物：
  描述：

  methyl (3R,4S)-6-methoxy-4-(2,4,5-trifluorophenyl)-2,3,4,5-tetrahydropyridine-3-carboxylate 、 二碳酸二叔丁酯 在 sodium tetrahydroborate 、 碳酸氢钠 作用下， 以 乙醇 、 四氢呋喃 、 水 为溶剂， 反应 20.0h， 生成 1-tert-butyl 3-methyl (3R,4S)-4-(2,4,5-trifluorophenyl)piperidine-1,3-dicarboxylate
  参考文献：
  名称：

  [EN] AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  [FR] AMINOPIPERIDINES UTILISEES COMME INHIBITEURS DE LA DIPEPTIDYLE PEPTIDASE-IV POUR LE TRAITEMENT OU LA PREVENTION DU DIABETE

  摘要：

  公开号：

  WO2006039325A3

文献信息

• Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
  申请人：Cox M. Jason

  公开号：US20080076773A1

  公开（公告）日：2008-03-27

  The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种新型的取代氨基哌啶，它是二肽基肽酶-IV酶（“DPP-IV酶”）的抑制剂，并且在治疗或预防DPP-IV酶参与的疾病，如糖尿病，尤其是2型糖尿病方面具有用处。本发明还涉及包含这些化合物的制药组合物，以及使用这些化合物和组合物在预防或治疗DPP-IV酶参与的这些疾病方面的用途。
• Aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07884104B2

  公开（公告）日：2011-02-08

  The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及新型取代氨基哌啶类化合物，它们是二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，如糖尿病，尤其是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在涉及二肽基肽酶-IV酶的这种疾病的预防或治疗中使用这些化合物和组合物。
• [EN] AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES<br/>[FR] AMINOPIPERIDINES UTILISEES COMME INHIBITEURS DE LA DIPEPTIDYLE PEPTIDASE-IV POUR LE TRAITEMENT OU LA PREVENTION DU DIABETE
  申请人：MERCK & CO INC

  公开号：WO2006039325A3

  公开（公告）日：2007-01-04