[diphenyl-[(2S)-2-prop-2-enoxybut-3-enoxy]methyl]benzene | 403985-94-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: [diphenyl-[(2S)-2-prop-2-enoxybut-3-enoxy]methyl]benzene
• CAS: 403985-94-4
• 化学式: C₂₆H₂₆O₂
• 分子量: 370.491
• InChiKey: OZVIZFUCYWXNIU-VWLOTQADSA-N

物化性质

• 沸点：
  475.0±33.0 °C(Predicted)
• 密度：
  1.053±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [diphenyl-[(2S)-2-prop-2-enoxybut-3-enoxy]methyl]benzene 在 Grubbs catalyst first generation 、 乙烯 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 生成 (2S,3R,4R)-3,4-epoxy-2-trityloxymethyl-tetrahydrofuran
  参考文献：
  名称：

  Synthesis of amino-1,4-anhydro-d-pentitols and amino-1,5-anhydro-d-hexitols with the arabino configuration from (R)-glycidol

  摘要：

  2-Amino-1,4-anhydro-pentitol and 3-amino-1,5-anhydro-4-deoxy-hexitol with the arabino configuration were synthesised from (R)-glycidol using a metathesis reaction as the key step. The dihydrofuran or dihydropyran products obtained after the metathesis reaction were subjected to epoxidation, epoxide opening with azide anion and finally azide reduction. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00325-2
• 作为产物：
  描述：

  三苯甲基-(S)-缩水甘油醚 在 正丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.5h， 生成 [diphenyl-[(2S)-2-prop-2-enoxybut-3-enoxy]methyl]benzene
  参考文献：
  名称：

  Synthesis of amino-1,4-anhydro-d-pentitols and amino-1,5-anhydro-d-hexitols with the arabino configuration from (R)-glycidol

  摘要：

  2-Amino-1,4-anhydro-pentitol and 3-amino-1,5-anhydro-4-deoxy-hexitol with the arabino configuration were synthesised from (R)-glycidol using a metathesis reaction as the key step. The dihydrofuran or dihydropyran products obtained after the metathesis reaction were subjected to epoxidation, epoxide opening with azide anion and finally azide reduction. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00325-2

文献信息

• FUSED AMINODIHYDROTHIAZINE DERIVATIVES
  申请人：Suzuki Yuichi

  公开号：US20120094984A1

  公开（公告）日：2012-04-19

  A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C 6-14 aryl group or the like, L is —NR e CO— or the like (wherein R e is a hydrogen atom or the like), Ring B is a C 6-14 aryl group or the like, X is a C 1-3 alkylene group or the like, Y is a single bond or the like, Z is a C 1-3 alkylene group or the like, R 1 and R 2 are each independently a hydrogen atom or the like, and R 3 , R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

  一种化合物，其一般式表示为：或其药物可接受的盐或溶剂化物，其中环A是C6-14芳基或类似物，L是—NReCO—或类似物（其中Re是氢原子或类似物），环B是C6-14芳基或类似物，X是C1-3烷基或类似物，Y是单键或类似物，Z是C1-3烷基或类似物，R1和R2各自独立地是氢原子或类似物，而R3、R4、R5和R6独立地是氢原子、卤素原子或类似物，具有Aβ产生抑制作用或BACE1抑制作用，可用作预防或治疗由Aβ引起的以阿尔茨海默型痴呆为特征的神经退行性疾病的药物。
• FUSED AMINODIHYDRO-OXAZINE DERIVATIVES
  申请人：Ellard John Mark

  公开号：US20120202804A1

  公开（公告）日：2012-08-09

  A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C 6-14 aryl group or the like, L is —NR e CO— or the like (wherein R e is a hydrogen atom or the like), Ring B is a C 6-14 aryl group or the like, X is a C 1-3 alkylene group or the like, Y is a single bond or the like, Z is a C 1-3 alkylene group or the like, R 1 and R 2 are each independently a hydrogen atom or the like, and R 3 , R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

  化合物由通式（I）或其药学上可接受的盐或溶剂化物表示，其中环A是C6-14芳基或类似物，L是-NReCO-或类似物（其中Re是氢原子或类似物），环B是C6-14芳基或类似物，X是C1-3烷基或类似物，Y是单键或类似物，Z是C1-3烷基或类似物，R1和R2各自独立地是氢原子或类似物，而R3、R4、R5和R6各自独立地是氢原子、卤原子或类似物。该化合物具有Aβ产生抑制作用或BACE1抑制作用，并且可用作预防或治疗由Aβ引起的、以阿尔茨海默型痴呆为代表的神经退行性疾病的药物。
• CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE
  申请人：Suzuki Yuichi

  公开号：US20100317850A1

  公开（公告）日：2010-12-16

  Disclosed is a compound represented by General formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the compound or the pharmaceutically acceptable salt, which has an inhibitory activity of the production of Aβ or a BACE1-inhibiting activity, and is therefore useful as a prophylactic or therapeutic agent for Aβ-induced neurodegenerative diseases typified by Alzheimer-type dementia. Wherein the ring A represents a C 6-14 aryl group or the like; L represents —NR e CO— [wherein R e represents a hydrogen atom or the like] or the like; the ring B represents a C 6-14 aryl group or the like; X represents a C 1-3 alkylene group or the like; Y represents a single bond or the like; Z represents a C 1-3 alkylene group or the like; R 1 and R 2 independently represent a hydrogen atom or the like; and R 3 , R 4 , R 5 and R 6 independently represent a hydrogen atom, a halogen atom or the like.

  本发明涉及一种由通式（I）表示的化合物，其药学上可接受的盐或该化合物或药学上可接受的盐的溶剂，该化合物具有抑制Aβ产生或BACE1抑制活性，因此可用作治疗由阿尔茨海默病等Aβ诱导的神经退行性疾病的预防或治疗剂。其中，环A表示C6-14芳基或类似物；L表示—NReCO—[其中Re表示氢原子或类似物]或类似物；环B表示C6-14芳基或类似物；X表示C1-3烷基或类似物；Y表示单键或类似物；Z表示C1-3烷基或类似物；R1和R2独立地表示氢原子或类似物；而R3、R4、R5和R6独立地表示氢原子、卤素原子或类似物。
• US8158620B2
  申请人：——

  公开号：US8158620B2

  公开（公告）日：2012-04-17
• US8946210B2
  申请人：——

  公开号：US8946210B2

  公开（公告）日：2015-02-03