(+/-)-2-(3-acetylamino-phenyl)-propionic acid | 103797-09-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (+/-)-2-(3-acetylamino-phenyl)-propionic acid
• 英文别名: (+/-)-2-(3-Acetylamino-phenyl)-propionsaeure；2-(3-Acetamidophenyl)propanoic acid
• CAS: 103797-09-7
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: BUFCFBNVZNMPTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (RS)-2-(3-硝基苯基)丙酸 在 乙醇 、 铂 作用下， 生成 (+/-)-2-(3-acetylamino-phenyl)-propionic acid
  参考文献：
  名称：

  99mTc-sestamibi muscle scintigraphy to assess the response to neuromuscular electrical stimulation of normal quadriceps femoris muscle

  摘要：

  Objectives: Neuromuscular electrical stimulation (NMES) is widely used for improving muscle strength by simultaneous contraction in the prevention of muscle atrophy. Although there exist many clinical methods for evaluating the therapeutic response of muscles, Tc-99m-sestamibi which is a skeletal muscle perfusion and metabolism agent has not previously been used for this purpose. The aim of our work was to ascertain whether Tc-99m-sestamibi muscle scintigraphy is useful in the monitoring of therapeutic response to NMES in healthy women.Methods: The study included 16 women aged between 21 and 45, with a mean age of 32.7 +/- 6.4. Both quadriceps femoris muscles (QFM) of each patient were studied. After randomization to remove the effect of the dominant side, one QFM of each patient was subjected to the NMES procedure for a period of 20 days. NMES was performed with an alternating biphasic rectangular current, from a computed electrical stimulator daily for 23 minutes. After measurement of skinfold thickness over the thigh, pre- and post-NMES girth measurements were assessed in centimeters. Sixty minutes after injections of 555 MBq Tc-99m-sestamibi, static images of the thigh were obtained for 5 minutes. The thigh-to-knee uptake ratio was calculated by semiquantitative analysis and normalized to body surface area (NUR = normalized uptake ratio).Results: The difference between the pre and post NMES NUR values was Significant (1.76 +/- 0.31 versus 2.25 +/- 0.38, p = 0.0000). The percentage (%) increase in NUR values also well correlated with the % increase in thigh girth measurements (r = 0.89, p = 0.0000).Conclusion: These results indicated that Tc-99m-sestamibi muscle scintigraphy as a new tool may be useful in evaluating therapeutic response to NMES.

  DOI：

  10.1007/bf02988252

文献信息

• Heterocyclic Kinase Inhibitors
  申请人：Hasvold A. Lisa

  公开号：US20070254867A1

  公开（公告）日：2007-11-01

  Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有公式的化合物对于抑制蛋白激酶很有用。还公开了制备这些化合物的方法、含有这些化合物的组合物和使用这些化合物的治疗方法。
• Tricyclic dihydropyridazinones and pharmaceutical compositions contaning them
  申请人：BOEHRINGER MANNHEIM ITALIA S.P.A.

  公开号：EP0169443A2

  公开（公告）日：1986-01-29

  The tricyclic dihydropyridazinone derivatives having formula I are endowed with interesting hypotensive, vasodilating, antiaggregant, antithrombotic and cytoprotective properties and are therefore useful in human or veterinary medicine.

  三环二氢哒嗪酮衍生物具有式 I 的三环二氢哒嗪酮衍生物具有有趣的降血压、血管扩张、抗聚集、抗血栓和细胞保护特性，因此可用于人类或兽医领域。
• US4250252A
  申请人：——

  公开号：US4250252A

  公开（公告）日：1981-02-10
• US4692447A
  申请人：——

  公开号：US4692447A

  公开（公告）日：1987-09-08
• US7456169B2
  申请人：——

  公开号：US7456169B2

  公开（公告）日：2008-11-25