(1S,2S)-2-[benzyl(methyl)amino]-1,2-diphenylethanol | 374776-79-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1S,2S)-2-[benzyl(methyl)amino]-1,2-diphenylethanol
• CAS: 374776-79-1
• 化学式: C₂₂H₂₃NO
• 分子量: 317.431
• InChiKey: XKGVODLIURNSDV-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二苯基氯化膦 、 (1S,2S)-2-[benzyl(methyl)amino]-1,2-diphenylethanol 在 4-二甲氨基吡啶 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以94%的产率得到(1S,2S)-N-benzyl-2-diphenylphosphanyloxy-N-methyl-1,2-diphenylethanamine
  参考文献：
  名称：

  Easily accessible chiral amino-phosphinite ligands for highly enantioselective palladium-mediated allylic alkylation

  摘要：

  Palladium-catalyzed asymmetric allylic alkylation of 1,3-diplienyl-2-propenyl acetate with the dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of easily prepared new chiral amino-phosphinite ligands such as 3b and 3c to result in good yields and excellent enantioselectivities of up to 95%, e.e. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00204-5
• 作为产物：
  描述：

  (1S,2s)-(-)-2-氨基-1,2-二苯基乙醇 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 12.5h， 生成 (1S,2S)-2-[benzyl(methyl)amino]-1,2-diphenylethanol
  参考文献：
  名称：

  Easily accessible chiral amino-phosphinite ligands for highly enantioselective palladium-mediated allylic alkylation

  摘要：

  Palladium-catalyzed asymmetric allylic alkylation of 1,3-diplienyl-2-propenyl acetate with the dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of easily prepared new chiral amino-phosphinite ligands such as 3b and 3c to result in good yields and excellent enantioselectivities of up to 95%, e.e. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00204-5

文献信息

• Easily accessible chiral amino-phosphinite ligands for highly enantioselective palladium-mediated allylic alkylation
  作者：Guoshu Chen、Xin Li、Haile Zhang、Liuzhu Gong、Aiqiao Mi、Xin Cui、Yaozhong Jiang、Michael C.K. Choi、Albert S.C. Chan

  DOI：10.1016/s0957-4166(02)00204-5

  日期：2002.5

  Palladium-catalyzed asymmetric allylic alkylation of 1,3-diplienyl-2-propenyl acetate with the dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of easily prepared new chiral amino-phosphinite ligands such as 3b and 3c to result in good yields and excellent enantioselectivities of up to 95%, e.e. (C) 2002 Published by Elsevier Science Ltd.