di(1-naphthyl) malonate | 15014-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: di(1-naphthyl) malonate
• 英文别名: Malonsaeure-bis-α-naphthylester；malonic acid di-[1]naphthyl ester；Malonsaeure-di-[1]naphthylester；Propanedioic acid, 1,3-di-1-naphthalenyl ester；dinaphthalen-1-yl propanedioate
• CAS: 15014-26-3
• 化学式: C₂₃H₁₆O₄
• 分子量: 356.378
• InChiKey: LRZYBECHHIARTH-UHFFFAOYSA-N

物化性质

• 熔点：
  128 °C(Solv: ethanol (64-17-5))
• 沸点：
  572.4±33.0 °C(Predicted)
• 密度：
  1.285±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  di(1-naphthyl) malonate 在 三氯化铝 作用下， 生成 4-hydroxy-benzo[h]chromen-2-one
  参考文献：
  名称：

  Zur Chemie des 4-Oxy-cumarins

  摘要：

  DOI：

  10.1007/bf00899270
• 作为产物：
  描述：

  3-(naphthalen-1-yloxy)-3-oxopropanoic acid 生成 di(1-naphthyl) malonate
  参考文献：
  名称：

  Eine einfache Synthese von Malonsäure-mono- und -bis-phenylestern¹

  摘要：

  DOI：

  10.1055/s-1976-24041

文献信息

• Method for Producing Fluorine-Containing Cyclopropane Carboxylic Acid Compound
  申请人：CENTRAL GLASS COMPANY, LIMITED

  公开号：US20180186763A1

  公开（公告）日：2018-07-05

  The present invention provides an industrially applicable method for production of a fluorine-containing cyclopropane carboxylic acid compound useful as an intermediate for pharmaceutical and agrichemical products. A fluorine-containing cyclopropane monoester is obtained by: forming a fluorine-containing cyclic sulfate with the use of a fluorine-containing dial compound and sulfuryl fluoride (as a cyclic sulfuric esterification step); reacting the fluorine-containing cyclic sulfate with a malonic diester, thereby forming a fluorine-containing cyclopropane diester (as a cyclopropanation step); and hydrolyzing the fluorine-containing cyclopropane diester (as a hydrolysis step). The fluorine-containing cyclopropane carboxylic acid compound, such as fluorine-containing cyclopropane monoester or its salt, can be obtained with high chemical and optical purity by mixing the fluorine-containing cyclopropane monoester with an amine and subjecting the resulting salt of the fluorine-containing cyclopropane monoester and amine to recrystallization purification.

  本发明提供了一种工业上可应用的生产含氟环丙烷羧酸化合物的方法，该化合物可用作制药和农药产品的中间体。通过以下步骤获得含氟环丙烷单酯：使用含氟二醇化合物和氟磺酰氟形成含氟环状硫酸酯（作为环状硫酸酯化步骤）；将含氟环状硫酸酯与丙二酸二酯反应，从而形成含氟环丙烷二酯（作为环丙烷化步骤）；并水解含氟环丙烷二酯（作为水解步骤）。通过将含氟环丙烷单酯与胺混合并将所得的含氟环丙烷单酯和胺的盐进行重结晶纯化，可以获得高化学和光学纯度的含氟环丙烷羧酸化合物，例如含氟环丙烷单酯或其盐。
• USE OF COUMARIN DERIVATIVES FOR THE PREPARATION OF DRUGS FOR TREATING SKIN DISEASES
  申请人：UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

  公开号：US20140148480A1

  公开（公告）日：2014-05-29

  A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a —O—R12 group, wherein R12 is a C1-C7 alkyl, a group —CH 2 —O—CO—R5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group —O—R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a —CH 2 — amine, R′1 represents a group chosen among hydrogen and —O—R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.

  化合物的公式（I-1），其中n等于0或1，Z代表O或S，R1代表从以下组中选择的一组基团，该组基团由氢，C1-C7烷基组成，被卤素，羟基或—O—R12基团取代或未取代，其中R12是C1-C7烷基，一个基团—CH2—O—CO—R5，其中R5选择氢原子和C1-C7烷基，被至少一个卤素取代或未取代，一个基团—O—R13，其中R13选择氢和C1-C7烷基，胺或—CH2—胺，R'1代表选择氢和—O—R14之一的基团，其中R14选择氢和C1-C7烷基，而R2选择在由C1-C7烷基，C3-C6环烷基，芳基和杂芳基组成的一组中，用于治疗涉及至少一种卡利克雷因家族成员过度活性的病理情况。
• Acrylate compound and composition containing the same
  申请人：TOKUYAMA SODA KABUSHIKI KAISHA

  公开号：EP0206810A2

  公开（公告）日：1986-12-30

  Disclosed is an acrylate compound represented by the following general formula: wherein R1 stands for a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R2 stands for an alkylene group having 2 to 20 carbon atoms, R3 stands for hydrogen atom or an alkyl group having 1 to 20 carbon atoms when n is 1, and n is 1 or 2 and adhesive compositions comprising this acrylate compound.

  本发明公开了一种由以下通式表示的丙烯酸酯化合物： 其中 R1 代表氢原子或具有 1 至 4 个碳原子的烷基，R2 代表具有 2 至 20 个碳原子的亚烷基，R3 代表氢原子或具有 1 至 20 个碳原子的烷基，当 n 为 1 时，n 为 1 或 2，以及包含这种丙烯酸酯化合物的粘合剂组合物。
• METHOD FOR PRODUCING FLUORINE-CONTAINING CYCLOPROPANE CARBOXYLIC ACID COMPOUND
  申请人：Central Glass Co., Ltd.

  公开号：EP3315497A1

  公开（公告）日：2018-05-02

  The present invention provides an industrially applicable method for production of a fluorine-containing cyclopropane carboxylic acid compound useful as an intermediate for pharmaceutical and agrichemical products. A fluorine-containing cyclopropane monoester is obtained by: forming a fluorine-containing cyclic sulfate with the use of a fluorine-containing diol compound and sulfuryl fluoride (as a cyclic sulfuric esterification step); reacting the fluorine-containing cyclic sulfate with a malonic diester, thereby forming a fluorine-containing cyclopropane diester (as a cyclopropanation step); and hydrolyzing the fluorine-containing cyclopropane diester (as a hydrolysis step). The fluorine-containing cyclopropane carboxylic acid compound, such as fluorine-containing cyclopropane monoester or its salt, can be obtained with high chemical and optical purity by mixing the fluorine-containing cyclopropane monoester with an amine and subjecting the resulting salt of the fluorine-containing cyclopropane monoester and amine to recrystallization purification.

  本发明提供了一种工业上适用的方法，用于生产一种可用作医药和农化产品中间体的含氟环丙烷羧酸化合物。含氟环丙烷单酯通过以下方法获得：使用含氟二元醇化合物和硫酰氟形成含氟环硫酸盐（作为环硫酸酯化步骤）；含氟环硫酸盐与丙二酸二酯反应，从而形成含氟环丙烷二酯（作为环丙烷化步骤）；以及水解含氟环丙烷二酯（作为水解步骤）。通过将含氟环丙烷单酯与胺混合，并将得到的含氟环丙烷单酯和胺的盐进行重结晶纯化，可以得到化学和光学纯度较高的含氟环丙烷羧酸化合物，如含氟环丙烷单酯或其盐。
• Method for producing fluorine-containing cyclopropane carboxylic acid compound
  申请人：Central Glass Company, Limited

  公开号：US10450291B2

  公开（公告）日：2019-10-22

  The present invention provides an industrially applicable method for production of a fluorine-containing cyclopropane carboxylic acid compound useful as an intermediate for pharmaceutical and agrichemical products. A fluorine-containing cyclopropane monoester is obtained by: forming a fluorine-containing cyclic sulfate with the use of a fluorine-containing dial compound and sulfuryl fluoride (as a cyclic sulfuric esterification step); reacting the fluorine-containing cyclic sulfate with a malonic diester, thereby forming a fluorine-containing cyclopropane diester (as a cyclopropanation step); and hydrolyzing the fluorine-containing cyclopropane diester (as a hydrolysis step). The fluorine-containing cyclopropane carboxylic acid compound, such as fluorine-containing cyclopropane monoester or its salt, can be obtained with high chemical and optical purity by mixing the fluorine-containing cyclopropane monoester with an amine and subjecting the resulting salt of the fluorine-containing cyclopropane monoester and amine to recrystallization purification.

  本发明提供了一种工业上适用的方法，用于生产一种可用作医药和农化产品中间体的含氟环丙烷羧酸化合物。含氟环丙烷单酯通过以下方法获得：使用含氟拨号化合物和硫酰氟形成含氟环硫酸盐（作为环硫酸酯化步骤）；含氟环硫酸盐与丙二酸二酯反应，从而形成含氟环丙烷二酯（作为环丙烷化步骤）；以及水解含氟环丙烷二酯（作为水解步骤）。通过将含氟环丙烷单酯与胺混合，并将得到的含氟环丙烷单酯和胺的盐进行重结晶纯化，可以得到化学和光学纯度较高的含氟环丙烷羧酸化合物，如含氟环丙烷单酯或其盐。