[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-(1-methyl-2,3,4,5-tetraphenylsilol-1-yl)propyl]carbamate | 1174270-22-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-(1-methyl-2,3,4,5-tetraphenylsilol-1-yl)propyl]carbamate
• CAS: 1174270-22-4
• 化学式: C₆₀H₇₅NO₂Si
• 分子量: 870.346
• InChiKey: MOQHXFVAKDNSGI-ZHRRHZEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.91
• 重原子数：
  64
• 可旋转键数：
  15
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-methyl-1-(3-amino)propyl-2,3,4,5-tetraphenylsilole 、 胆固醇甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以46%的产率得到[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-(1-methyl-2,3,4,5-tetraphenylsilol-1-yl)propyl]carbamate
  参考文献：
  名称：

  Fluorescence enhancement upon gelation and thermally-driven fluorescence switches based on tetraphenylsilole-based organic gelators

  摘要：

  Two new organic gelators 1 and 2 based on the silole (silacyclopentadiene) framework were designed with the end to develop switchable fluorescent organogels, by making use of the aggregation-induced emission (AIE) feature of silole derivatives. As for other silole derivatives, compounds 1 and 2 exhibited AIE behavior as indicated by the significant fluorescence enhancement by introducing water to the THF solutions. Compounds 1 and 2 can gel hexane, methylcyclohexane and heptane. Large fluorescence enhancement was observed for compounds 1 and 2 after gelation. Moreover, their fluorescence intensities can be changed reversibly accompanying the gel-solution transition through alternating cooling and heating. Therefore, thermally-driven fluorescence switches can be achieved with organogels based on 1 and 2. (c) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cplett.2009.05.029

文献信息

• Fluorescence enhancement upon gelation and thermally-driven fluorescence switches based on tetraphenylsilole-based organic gelators
  作者：Ming Wang、Deqing Zhang、Guanxin Zhang、Daoben Zhu

  DOI：10.1016/j.cplett.2009.05.029

  日期：2009.6

  Two new organic gelators 1 and 2 based on the silole (silacyclopentadiene) framework were designed with the end to develop switchable fluorescent organogels, by making use of the aggregation-induced emission (AIE) feature of silole derivatives. As for other silole derivatives, compounds 1 and 2 exhibited AIE behavior as indicated by the significant fluorescence enhancement by introducing water to the THF solutions. Compounds 1 and 2 can gel hexane, methylcyclohexane and heptane. Large fluorescence enhancement was observed for compounds 1 and 2 after gelation. Moreover, their fluorescence intensities can be changed reversibly accompanying the gel-solution transition through alternating cooling and heating. Therefore, thermally-driven fluorescence switches can be achieved with organogels based on 1 and 2. (c) 2009 Elsevier B.V. All rights reserved.